Levels of oestrogen receptor, progesterone receptor and αB-crystallin in eutopic endometrium in relation to pregnancy in women with endometriosis

Christian Moberg, Vladimir Bourlev, N. A. Ilyasova, Natalia Ilyasova, Matts Olovsson
Human fertility (Cambridge, England) · 2014 · vol. 18(1) , pp. 30–37 · doi:10.3109/14647273.2014.922705 · PMID:24945100 · W2027676582
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Endometrial ER-α and PR levels differed between women with endometriosis who did or did not achieve pregnancy, with αB-crystallin levels correlating with pregnancy likelihood.

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Abstract

Endometriosis affects fertility in many women and may partly be due to decreased endometrial receptivity. Several mechanisms have been suggested, notably, progesterone resistance for which a number of candidate biomarkers have been suggested. Here we demonstrate aberrant levels of steroid hormone receptors and the small heat shock protein αB-crystallin in eutopic endometrial epithelium from 38 women with peritoneal endometriosis diagnosed during investigation for secondary infertility. Spontaneous pregnancies within 1 year after medical and surgical treatment for endometriosis were recorded and semi-quantitative immunohistochemistry data compared between women with endometriosis who did or did not become pregnant and healthy controls. Stronger immunostaining for ER-α was detected in luminal and glandular endometrial epithelium from women with endometriosis who did not become pregnant during the post-treatment observation period versus endometriosis patients who became pregnant and controls. Staining levels of PR and PR-B were lower in patients without subsequent pregnancies than in the two other groups. Endometrial levels of αB-crystallin in endometriosis patients similar to those in controls were strongly correlated with the chance of becoming pregnant, whereas higher or lower levels were not.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

alpha-Crystallin B Chain Endometriosis Endometrium Estrogen Receptor alpha Infertility, Female Peritoneal Diseases Receptors, Progesterone Adult alpha-Crystallin B Chain Biomarkers Biomarkers Biopsy Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Estrogen Receptor alpha Estrogen Receptor beta

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