Differential Proteome Profiling of Eutopic Endometrium from Women with Endometriosis To Understand Etiology of Endometriosis

Priyanka Rai, Venkatesh Kota, Mamata Deendayal, Sisinthy Shivaji, S. Shivaji
Journal of proteome research · 2010 · vol. 9(9) , pp. 4407–4419 · doi:10.1021/pr100657s · PMID:20690674 · W1996356663
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Proteomic analysis of eutopic endometrium identified over 70 differentially expressed proteins in women with endometriosis, revealing dysregulation in various cellular processes that may contribute to the disease's pathogenesis.

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Abstract

The identification of molecular differences in the endometrium of women with endometriosis is an important step toward understanding the pathogenesis of this condition and for developing novel strategies for the treatment of associated infertility and pain. In this study, we investigated protein expression analysis of eutopic endometrium from women with and without endometriosis. The proteomic analysis revealed molecular dysregulation of more than 70 proteins in the proliferative phase of eutopic endometrium in stage IV and secretory phase of stage II, III and IV endometriosis. Using mass spectrometry, 48 proteins spots which were consistently differentially expressed from stage II to IV endometriosis were identified. The differentially expressed proteins include structural proteins, proteins involved in stress response, protein-folding and protein-turnover, immunity, energy production, signal transduction, RNA biogenesis, protein biosynthesis, and nuclear proteins. Immunoblot and immunohistochemical analyses confirmed the observed changes in eight representative proteins. The present study provides identification of new players that have a potential role in the initiation and progression of endometriosis and also sets a framework for further investigations on mechanisms underlying the pathogenesis of endometriosis.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Endometriosis Proteome Proteomics Adult Electrophoresis, Gel, Two-Dimensional Endometriosis Endometrium Endometrium Endometrium Female Follicular Phase Follicular Phase Heat-Shock Proteins Heat-Shock Proteins Humans Immunoblotting Immunohistochemistry Luteal Phase Luteal Phase Proteome

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