Infertility: Expression of heat shock protein 70 kDa in human endometrium of normal and infertile women

M M Nip, MARIA M. C. NIP, Douglas L. Miller, D Miller, P V Taylor, M J Gannon, M. Gannon, K W Hancock
Human Reproduction · 1994 · vol. 9(7) , pp. 1253–1256 · doi:10.1093/oxfordjournals.humrep.a138689 · PMID:7962428 · W2255195597
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This study found significantly higher expression of heat shock protein 70 kDa in the endometrium of infertile women, suggesting a stress response may contribute to unexplained infertility.

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Abstract

The expression of heat shock protein (hsp) 70 was investigated in endometrial samples from patients with unexplained infertility associated (n = 5) or not associated (n = 10) with endometriosis, and compared with a control group consisting of fertile women (n = 27) with reported menstrual disturbance. The expression of hsp, and in particular hsp 70, is up-regulated in response to many physico-biochemical insults as well as infection and possibly oncogenic transformation and is a good indicator of a biological system under stress. A significant over-expression of hsp 70 was found in the infertile groups (P < 0.001), suggesting that a stress response may be involved in the aetiology of unexplained infertility irrespective of the presence of endometriosis.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometrium HSP70 Heat-Shock Proteins Infertility, Female Adult Endometriosis Endometriosis Endometriosis Endometrium Female HSP70 Heat-Shock Proteins Humans Infertility, Female Infertility, Female Middle Aged Stress, Physiological Stress, Physiological Stress, Physiological Up-Regulation

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (7)

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