Expression of heat shock protein 70 kDa in human endometrium of normal and infertile women
Non-randomised trial
OA: closed
CC0
⤵ 7 in-corpus citations
AI-generated summary
This study found significantly higher expression of heat shock protein 70 kDa in the endometrium of infertile women, suggesting a stress response may contribute to unexplained infertility.
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Abstract
The expression of heat shock protein (hsp) 70 was investigated in endometrial samples from patients with unexplained infertility associated (n = 5) or not associated (n = 10) with endometriosis, and compared with a control group consisting of fertile women (n = 27) with reported menstrual disturbance. The expression of hsp, and in particular hsp 70, is up-regulated in response to many physico-biochemical insults as well as infection and possibly oncogenic transformation and is a good indicator of a biological system under stress. A significant over-expression of hsp 70 was found in the infertile groups (P < 0.001), suggesting that a stress response may be involved in the aetiology of unexplained infertility irrespective of the presence of endometriosis.
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Cited by (7)
- Differential proteome profiling of eutopic endometrium from women with endometriosis to understand etiology of endometriosis 2010
- Measurable serum markers of oxidative stress response in women with endometriosis 2008
- Endometrial anomalies in women with endometriosis 2001
- Theories of endometriosis 2001
- Is endometriosis an endometrial disease? 2000
- Is adenomyosis an immune disease? 1998
- Distribution of heat shock proteins in eutopic and ectopic endometrium in endometriosis and adenomyosis 1997
Source provenance
- europepmc
- last seen: 2026-10-13T06:10:10.580696+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-10-08T21:59:14.651011+00:00
- unpaywall
- last seen: 2026-10-13T06:25:51.201866+00:00
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