Women with advanced-stage endometriosis and previous surgery respond less well to gonadotropin stimulation, but have similar IVF implantation and delivery rates compared with women with tubal factor infertility

Ioannis M Matalliotakis, Ioannis Matalliotakis, Matalliotakis IM, Hakan Çakmak, Cakmak H, Hakan Cakmak, Mahutte N, Neal Mahutte, Yvoni Fragouli, Fragouli Y, Aydın Arıcı, Aydin Arici, Arici A, Denny Sakkas, Sakkas D
Fertility and sterility · 2007 · vol. 88(6) , pp. 1568–1572 · doi:10.1016/j.fertnstert.2007.01.037 · PMID:17349642 · W2064906220
article OA: bronze CC0 ⤵ 82 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

Women with advanced endometriosis and prior surgery showed reduced ovarian response to gonadotropin stimulation but achieved comparable IVF implantation and delivery rates to women with tubal factor infertility.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo investigate the response to controlled ovarian hyperstimulation and ART outcomes in women with advanced-stage endometriosis and previous surgeries at the Yale IVF program between 1996 and 2002.DesignRetrospective case control study.SettingAcademic medical center.Patient(s)The study group consisted of 68 women who previously undergone laparoscopic surgery for advanced-stage endometriosis. The control group included 106 women with tubal-factor infertility. The women with endometriosis underwent 133 IVF-ET cycles and the control group 208 cycles.Intervention(s)Controlled ovarian hyperstimulation and IVF-ET.Main outcome measure(s)Response to gonadotropins, fertilization, cleavage, implantation, pregnancy, miscarriage, and live birth rates.Result(s)Lower peak E(2) levels, higher total gonadotropin requirements, lower oocyte yield, and higher cancellation rates were found in women with endometriosis compared with tubal-factor control subjects. However, no differences were found in fertilization, cleavage, implantation, pregnancy, miscarriage, and delivery rates between the endometriosis and tubal-factor groups.Conclusion(s)Women with advanced-stage endometriosis who have undergone previous surgery respond less well to gonadotropins than women with tubal-factor infertility. However, implantation, pregnancy, and delivery rates are similar, suggesting that embryo quality and uterine receptivity remains unaffected despite diminished ovarian reserve in women with endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosisinfertility

MeSH descriptors

Embryo Implantation Embryo Implantation Endometriosis Fertilization in Vitro Fertilization in Vitro Gonadotropins Infertility, Female Ovulation Induction Ovulation Induction Pregnancy Rate Adult Case-Control Studies Delivery, Obstetric Endometriosis Endometriosis Endometriosis Female Gonadotropins Humans Infertility, Female

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (32)

Cited by (50)

Source provenance

europepmc
last seen: 2026-08-04T06:16:37.499272+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:15:00.519696+00:00
License: CC0 · commercial use OK