Use of medroxyprogesterone acetate in women with ovarian endometriosis undergoing controlled ovarian hyperstimulation for in vitro fertilization

Haiyan Guo, Yun Wang, Qiuju Chen, Weiran Chai, Lihua Sun, Ai Ai, Yonglun Fu, Qifeng Lyu, Yanping Kuang
Scientific reports · 2017 · vol. 7(1) , pp. 11927 · doi:10.1038/s41598-017-12151-7 · PMID:28931865 · W2755480203
article OA: gold CC0 ⤵ 10 in-corpus citations
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Medroxyprogesterone acetate (MPA) controlled ovarian hyperstimulation demonstrated higher mature oocyte and high-quality embryo rates compared to a short protocol in women with advanced ovarian endometriosis undergoing IVF.

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Abstract

This study investigated the use of medroxyprogesterone acetate (MPA) or a short protocol for controlled ovarian hyperstimulation (COH) in patients with advanced endometriosis who have normal ovarian function, and to compare cycle characteristics and pregnancy outcomes after frozen-thawed embryo transfer (FET). This was a retrospective case-control study of 244 patients with advanced endometriosis undering COH. The patients were allocated to three groups: the surgery group with MPA COH (62 patients, 71 IVF/ICSI cycles, 78 FET cycles); the aspiration group with MPA COH (85 patients had ovarian "chocolate" cysts (>3 cm) aspirated, 90 IVF/ICSI cycles, 76 FET cycles); and the short protocol group (97 patients, 101 IVF/ICSI cycles, 51 FET cycles). The results showed that higher rates of mature oocyte, D3 high quality embryo, hMG dose were observed in the two study groups using MPA compared with the short protocol. The number of >10-14 mm follicles on the trigger day, D3 top-quality embryos, viable embryos, rates of cancellation, fertilization, implantation, pregnancy outcomes were similar among the three groups. The oocytes, embryos, and pregnancy outcomes were not influenced by endometrioma surgery or presence of endometrioma. MPA COH could be effective for women with ovarian advanced endometriosis who had normal ovarian function.

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Condition tags

mesh:D004715endometriosisendometrioma

MeSH descriptors

Contraceptive Agents, Female Endometriosis Fertilization in Vitro Medroxyprogesterone Acetate Ovulation Induction Adult Case-Control Studies Contraceptive Agents, Female Endometriosis Female Fertilization in Vitro Humans Medroxyprogesterone Acetate Ovulation Induction Pregnancy Pregnancy Outcome Retrospective Studies Young Adult

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