Follicular fluid levels of prostaglandin E2 and the effect of prostaglandin E2 on steroidogenesis in granulosa-lutein cells in women with moderate and severe endometriosis undergoing in vitro fertilization and embryo transfer.
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This study found increased prostaglandin E2 and progesterone in endometriotic follicular fluid, with PGE2 enhancing progesterone and StAR but not estradiol production in granulosa-lutein cells from women with endometriosis.
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Abstract
BACKGROUND: The mechanisms of endometriosis with infertility have not been fully studied. The present study aimed to assess the follicular fluid (FF) levels of prostaglandin E2 (PGE2), which plays a critical role within the ovary, and to investigate the effect of PGE2 on steroidogenesis in granulosa-lutein cells (GLCs) from women with and without endometriosis. METHODS: Thirty-three women with laparoscopically documented endometriosis and 40 controls undergoing in vitro fertilization (IVF) were studied. We assayed the concentrations of PGE2 in FF, the production of E2 and progesterone in FF and in culture medium, and the expression of steroidogenic acute regulatory protein (StAR) and CYP19A1 in GLCs with the intervention of PGE2. RESULTS: PGE2 and progesterone concentrations were increased and displayed positive correlation in endometriotic FF. PGE2 induced the expression of StAR and the production of progesterone in GLCs from women with endometriosis, and the expression of StAR and the production of progesterone were increased in GLCs from women with endometriosis. However, there were no significant effects of PGE2 on promoting the production of E2 or the expression of CYP19A1 in GLCs. Moreover, the production of E2 and the expression of CYP19A1 in GLCs from women with endometriosis were significantly decreased compared to the controls. CONCLUSIONS: PGE2 concentrations are increased in endometriotic FF, along with concomitant increases in progesterone and StAR. In contrast, the E2 and CYP19A1 are decreased in GLCs, which may delay the development of the follicles and cause an imbalance in the follicular steroid hormone levels. These changes may have close relationship with endometriosis-associated infertility.
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Cited by (13)
- Mechanisms of Endometrioma-Mediated Ovarian Damage: Myths and Facts 2025
- Impact of endometriosis on the ovarian follicles 2023
- The relationship between CYP19A1 gene expression in luteinized granulosa cells and follicular estradiol output in women with endometriosis 2023
- Circular RNA Expression Profiling and Bioinformatic Analysis of Cumulus Cells in Endometriosis Infertility Patients 2020
- Peripheral Estrogens in Women with Endometriosis Undergoing IVF 2020
- Induction of autophagy by Beclin-1 in granulosa cells contributes to follicular progesterone elevation in ovarian endometriosis 2020
- L-carnitina e ácidos graxos ômega-3 previnem danos meióticos em oócitos bovinos maturados >i<in vitro>/i< com fluido folicular de mulheres inférteis com endometriose 2019
- Use of medroxyprogesterone acetate in women with ovarian endometriosis undergoing controlled ovarian hyperstimulation for in vitro fertilization 2017
- Metabolomic profiling in follicular fluid of patients with infertility-related deep endometriosis 2017
- Epigenetic alterations of CYP19A1 gene in Cumulus cells and its relevance to infertility in endometriosis 2016
- RCT to evaluate the influence of adjuvant medical treatment of peritoneal endometriosis on the outcome of IVF 2016
- Anatomy, Development, Histology, and Normal Function of the Ovary 2014
- Characteristic cytoplasmic morphology of oocytes in endometriosis patients and its effect on the outcome of assisted reproduction treatments cycles 2014
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- europepmc
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- openalex
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- pubmed
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