Follicular fluid levels of prostaglandin E2 and the effect of prostaglandin E2 on steroidogenesis in granulosa-lutein cells in women with moderate and severe endometriosis undergoing in vitro fertilization and embryo transfer

Wang J, Jing Wang, Shen XX, Xin-xin Shen, Xinxin Shen, Huang XH, Xiang-hua Huang, Xianghua Huang, Zhao ZM, Zhi-ming Zhao, Zhiming Zhao
Chinese medical journal · 2012 · vol. 125(22) , pp. 3985–90 · PMID:23158130 · W2431580519
Other OA: closed CC0 ⤵ 13 in-corpus citations
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This study found increased prostaglandin E2 and progesterone in endometriotic follicular fluid, with PGE2 enhancing progesterone and StAR but not estradiol production in granulosa-lutein cells from women with endometriosis.

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Abstract

BACKGROUND: The mechanisms of endometriosis with infertility have not been fully studied. The present study aimed to assess the follicular fluid (FF) levels of prostaglandin E2 (PGE2), which plays a critical role within the ovary, and to investigate the effect of PGE2 on steroidogenesis in granulosa-lutein cells (GLCs) from women with and without endometriosis. METHODS: Thirty-three women with laparoscopically documented endometriosis and 40 controls undergoing in vitro fertilization (IVF) were studied. We assayed the concentrations of PGE2 in FF, the production of E2 and progesterone in FF and in culture medium, and the expression of steroidogenic acute regulatory protein (StAR) and CYP19A1 in GLCs with the intervention of PGE2. RESULTS: PGE2 and progesterone concentrations were increased and displayed positive correlation in endometriotic FF. PGE2 induced the expression of StAR and the production of progesterone in GLCs from women with endometriosis, and the expression of StAR and the production of progesterone were increased in GLCs from women with endometriosis. However, there were no significant effects of PGE2 on promoting the production of E2 or the expression of CYP19A1 in GLCs. Moreover, the production of E2 and the expression of CYP19A1 in GLCs from women with endometriosis were significantly decreased compared to the controls. CONCLUSIONS: PGE2 concentrations are increased in endometriotic FF, along with concomitant increases in progesterone and StAR. In contrast, the E2 and CYP19A1 are decreased in GLCs, which may delay the development of the follicles and cause an imbalance in the follicular steroid hormone levels. These changes may have close relationship with endometriosis-associated infertility.

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Condition tags

endometriosisinfertility

MeSH descriptors

Dinoprostone Embryo Transfer Embryo Transfer Endometriosis Fertilization in Vitro Fertilization in Vitro Follicular Fluid Adult Adult Dinoprostone Dinoprostone Endometriosis Endometriosis Female Female Follicular Fluid Follicular Fluid Humans Humans Luteal Cells

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