Current place of progestins in the treatment of endometriosis-related complaints

Karl-Werner Schweppe, K W Schweppe, Schweppe KW
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2001 · vol. 15(sup6) , pp. 22–28 · doi:10.1080/gye.15.s6.22.28 · PMID:12227883 · W2182124214
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Progestins have been used for over 40 years to manage endometriosis complaints by inhibiting implant proliferation and inducing regressive changes, requiring repeat medication due to the chronic nature of the disease.

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Abstract

Oral progestins have been used for the treatment of endometriosis and endometriosis-associated complaints for more than 40 years. The mechanism of action on the menstrual cycle is well understood; however, the mechanism of action on endometriosis is still a matter of debate. The different progestins are able to stop proliferation in endometriotic implants and to induce regressive change to certain degrees; they are not able to heal endometriosis because endometriosis is a chronic and recurrent disease. For this reason, no medical treatment can heal endometriosis and repeat medication is necessary in the medical management of this disease. Progestins--especially non-androgenic progestins--are well tolerated and have only few side-effects; they can be used repeatedly or continuously over a long period of time.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Progestins Cell Division Cell Division Endometriosis Endometriosis Endometriosis Female Humans Progestins Progestins Recurrence

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (26)

Cited by (43)

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