Megestrol acetate for treatment of endometriosis.
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Megestrol acetate at 40 mg daily for up to 24 months relieved endometriosis symptoms in 86% of women previously unresponsive to other treatments, with manageable side effects.
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Abstract
Between 1977-1989, 29 women with symptomatic endometriosis were treated with megestrol acetate by the Johns Hopkins Division of Reproductive Endocrinology. All had previously received one or more alternative medical treatments for endometriosis, in each case discontinued because of poor response or development of unacceptable side effects. Treatment consisted of a daily dose of 40 mg megestrol acetate orally for up to 24 months. Disease-related symptoms (dysmenorrhea, noncyclic pelvic pain, and dyspareunia) were relieved in 86% of the subjects treated with an adequate course of therapy. Side effects were fairly well tolerated, although eight women discontinued treatment within 2 months and two others stopped the drug by 4 months. These preliminary findings suggest that megestrol acetate may be an effective treatment for patients with endometriosis, even those who have been unresponsive to other modes of therapy.
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Cited by (21)
- Endometriosis in Adolescent Girls 2020
- Systematic review of endometriosis pain assessment: how to choose a scale? 2014
- Progestin therapy for endometrial cancer: The potential of fourth-generation progestin (Review) 2012
- Use of Norethindrone Acetate Alone for Postoperative Suppression of Endometriosis Symptoms 2011
- Progestins for the Treatment of Endometriosis: An Update: 2010
- Current pharmacotherapy for endometriosis 2010
- Current Approaches to Optimizing the Treatment of Endometriosis in Adolescents 2008
- The role of progestins in treating the pain of endometriosis 2006
- Endometriosis: Treatment Strategies 2003
- Medical Therapy for Endometriosis 2003
- Endometriosis: current concepts and therapy 2002
- Current place of progestins in the treatment of endometriosis-related complaints 2001
- Endometriosis: An Overview of the Disease and Its Treatment 2000
- Medical Treatment of Endometriosis 1999
- Medical Treatment of Endometriosis-Associated Pain 1999
- Progestins for symptomatic endometriosis: a critical analysis of the evidence 1997
- Pain recurrence: A quality of life issue in endometriosis 1995
- Management of Recurrent Endometriosis After Hysterectomy and Bilateral Salpingo-Oophorectomy 1995
- Gonadotropin-releasing hormone agonist plus estrogen-progestin “add-back” therapy for endometriosis-related pelvic pain 1993
- Changing concepts of medical treatment of endometriosis 1993
- MANAGEMENT OF ENDOMETRIOSIS IN WOMEN OLDER THAN 40 YEARS OF AGE 1993
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