Effect of progestogens and combined oral contraceptives on nerve fibers in peritoneal endometriosis

Tokushige N, Natsuko Tokushige, Robert Markham, Markham R, Peter Russell, Russell P, Ian S Fraser, Fraser IS
Fertility and sterility · 2008 · vol. 92(4) , pp. 1234–1239 · doi:10.1016/j.fertnstert.2008.07.1774 · PMID:18976764 · W2024556033
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study investigated how progestogens and combined oral contraceptives affect nerve fibers within peritoneal endometriosis lesions.

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Abstract

ObjectiveTo investigate how progestogens and combined oral contraceptives change nerve fiber density in peritoneal endometriotic lesions and to identify the types of nerve fibers still present during hormone treatment.DesignLaboratory study using human tissue.SettingUniversity-based laboratory.Patient(s)Hormonally treated and untreated women with endometriosis undergoing laparoscopy, hysteroscopy, and curettage.Intervention(s)Biopsy samples from peritoneal endometriotic lesions in hormonally treated and untreated women with endometriosis.Main outcome measure(s)Types and density of nerve fibers were immunohistochemically determined in peritoneal endometriotic lesions from hormonally treated and untreated women with endometriosis.Result(s)The nerve fiber density (mean +/- standard deviation/mm(2)) in peritoneal endometriotic lesions from hormone-treated women with endometriosis (10.6 +/- 2.2/mm(2)) was statistically significantly lower than in peritoneal endometriotic lesions from untreated women with endometriosis (16.3 +/-10.0/mm(2)). Nerve growth factor and nerve growth factor receptor p75 expression in peritoneal endometriotic lesions were slightly reduced in hormone-treated women with endometriosis compared with untreated women with endometriosis.Conclusion(s)Progestogens and combined oral contraceptives reduced nerve fiber density and nerve growth factor and nerve growth factor receptor p75 expression in peritoneal endometriotic lesions.

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Condition tags

endometriosis

MeSH descriptors

Contraceptives, Oral, Combined Endometriosis Nerve Fibers Peritoneal Diseases Progestins Adolescent Adult Biopsy Case-Control Studies Cell Count Contraceptives, Oral, Combined Endometriosis Endometriosis Female Humans Middle Aged Nerve Fibers Nerve Fibers Nerve Fibers Nerve Growth Factor

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