Green Tea for Endometriosis

Gene Chi Wai Man, Hui Xu, Chi Chiu
In: Endometriosis - Basic Concepts and Current Research Trends · 2012 · doi:10.5772/28874 · W1603719273
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This paper discusses endometriosis, its prevalence, symptoms, and the limitations of current treatments, highlighting the need for therapies that target the disease itself and improve patient outcomes.

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This chapter reviews the potential therapeutic applications of green tea, specifically its polyphenol epigallocatechin-3-gallate (EGCG), in managing endometriosis. The authors highlight that EGCG exhibits anti-inflammatory, anti-proliferative, and pro-apoptotic properties that may inhibit the growth of ectopic endometrial cells and reduce associated pain. Evidence suggests that green tea extracts can modulate hormone receptors and angiogenesis, which are key drivers of endometrial lesion progression. This paper is centrally about endometriosis — specifically examining the molecular mechanisms by which green tea compounds may offer a complementary treatment strategy for the condition.

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Abstract

Endometriosis is a common gynaecological disease, defined by the presence of endometrial tissue outside the uterus, causing pain and infertility of women in reproductive age (Galle, 1989). It is estimated that it occurs in 10-15% for women in the reproductive age and more than 30% of all infertile women are affected (Cramer et al., 2002). However, the actual figure on the total prevalence may even be higher, as the disease is often not diagnosed due to heterogenous clinical manifestations. These manifestations include dysmenorrhoea, dyspareunia, dysuria and chronic abdominal or pelvic pain as well as infertility, resulting in a severely limited quality of life (Davis et al., 2003; Milingos et al., 2006; Vercellini et al., 2007). Thus, the aim on treating endometriosis should ideally target the endometriosis itself, i.e. relieves pain, promotes fertility and prevents reocurrence. Unfortunately, there is no current treatment being able to fulfill all these requirements. All conservative treatments, either medical or surgical, are still liable for disease reocurrence, and they do not address the cause and possible side effects brought upon to the disease mechanism and the patient outcomes.
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Open access Submitted: 03 March 2011 Published: 09 May 2012 DOI: 10.5772/28874 From the Edited Volume Edited by Koel Chaudhury and Baidyanath Chakravarty Submitted: 03 March 2011 Published: 09 May 2012 © 2012 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Discover 2026 Nobel Laureate Francis Halzen’s chapter on IntechOpen >

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endometriosisdysmenorrheadyspareuniainfertility

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