A review of current management of endometriosis in 2006: an evidence-based approach

Hansen KA, Keith A. Hansen, Eyster KM, Kathleen M. Eyster
South Dakota medicine : the journal of the South Dakota State Medical Association · 2006 · vol. 59(4) , pp. 153–9 · PMID:16681164 · W42816603
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This review outlines evidence-based treatments for endometriosis-associated infertility and pain, including conservative surgery, assisted reproductive technologies, and hormonal therapies, with future promise in genomics.

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Abstract

Endometriosis, a common cause of morbidity in reproductive age females, results in pelvic pain and infertility. Effective, evidence-based treatments of endometriosis-associated infertility include conservative surgical therapy and assisted reproductive technologies. In early stage endometriosis ovulation induction, with or without intrauterine insemination, improves pregnancy rates. In early stage disease in vitro fertilization reduces time to pregnancy as compared to controls, but does not increase the chance of pregnancy after three years. Endometriosis-associated pain can be approached with surgical or medical therapies. Conservative surgery maintains the reproductive organs and is an effective mode of treatment for endometriosis-associated pain. A more radical surgical approach of hysterectomy with bilateral salpingo-oophorectomy, not investigated in randomized controlled trials, remains a mainstay of therapy for endometriosis-associated pain in patients who have completed child-bearing. Current medical therapies rely upon interruption of normal cyclic, ovarian hormone production resulting in an environment not conducive to the growth of endometriosis. The current accepted therapies for endometriosis include danazol, progestational agents, oral contraceptive agents, and gonadotropin-releasing hormone analogues which all function similarly in relieving pain. The new era of genomics promises to help characterize endometriosis and allow one to tailor therapies based on a woman's symptoms and reproductive goals.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Contraceptive Agents, Female Contraceptive Agents, Female Contraceptive Agents, Female Estrogen Antagonists Estrogen Antagonists Estrogen Antagonists Evidence-Based Medicine Evidence-Based Medicine Female Female Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (13)

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License: CC0 · commercial use OK