Aromatase inhibitors prevent the estrogen rise associated with the flare effect of gonadotropins in patients treated with GnRH agonists

Mohamed A. Bedaiwy, Noha A. Mousa, Casper RF, Robert F. Casper
Fertility and sterility · 2008 · vol. 91(4) , pp. 1574–1577 · doi:10.1016/j.fertnstert.2008.09.077 · PMID:18973892 · W2059290856
Non-randomised trial OA: bronze CC0 ⤵ 17 in-corpus citations
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This study investigated how aromatase inhibitors affect the estrogen surge observed when gonadotropins are administered to patients already undergoing treatment with GnRH agonists.

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Abstract

This was a preliminary study to determine the effect of aromatase inhibitors in preventing the flare induced by GnRH agonist (GnRH-a) in women with endometriosis (n = 9) or leiomyomata (n = 4) who were given letrozole on the first 5 days of the GnRH-a therapy. Serum LH and FSH levels showed the typical flare 1 day after the injection of the GnRH-a; however, E(2) declined immediately after letrozole administration and was notably suppressed at 1, 2, and 4 days after GnRH-a. No patients complained of clinical symptoms typical of the GnRH-a flare phenomenon.

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Condition tags

endometriosis

MeSH descriptors

Aromatase Inhibitors Endometriosis Estrogens Gonadotropin-Releasing Hormone Leiomyoma Leuprolide Nitriles Triazoles Adult Adult Aromatase Inhibitors Aromatase Inhibitors Endometriosis Endometriosis Endometriosis Estrogens Estrogens Female Female Follicle Stimulating Hormone

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