Traitement de l’endométriose par les inhibiteurs de l’aromatase : efficacité thérapeutique et conséquences osseuses

A.-C. Racine, A-C Racine, Racine AC, Érick Legrand, E Legrand, Legrand E, C Lefebvre-Lacoeuille, C. Lefebvre-Lacœuille, Lefebvre-Lacoeuille C, E Hoppe, E. Hoppé, Hoppe E, L Catala, Catala L, Loı̈c Sentilhes, L Sentilhes, Sentilhes L, P Descamps, Descamps P
Gynecologie, obstetrique & fertilite · 2010 · vol. 38(5) , pp. 318–323 · doi:10.1016/j.gyobfe.2010.03.005 · PMID:20430665 · W2154599588
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper reviews the therapeutic efficacy and bone-related consequences of using aromatase inhibitors to treat endometriosis.

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Abstract

The recent demonstration that aromatase is expressed at higher levels in endometriosis implants than in normal endometrium has led to pilot studies using inhibitor aromatasis in patients with endometriosis. We conducted a systematic review of the literature and studied the efficacy of aromatase inhibitors on endometriosis. There were seventeen studies (case reports/series) evaluating outcomes of aromatase inhibitors. Studies suggest that aromatase inhibitors alone or co-administered with progestins, oral contraceptives or gonadotrophin releasing hormone (GnRH) agonist could reduce pain and endometriosis. There is only one randomized controlled trial comparing aromatase inhibitor+GnRH agonist and GnRH agonist and one study with eighty patients. Side-effects profiles of aromatase inhibitor regimens are favorable; it does not appear a significant bone loss. Aromatase inhibitors seem to have a promising effect on endometriosis but randomized controlled trials are needed to prove their effects and their safety.

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Condition tags

endometriosis

MeSH descriptors

Aromatase Inhibitors Aromatase Inhibitors Endometriosis Osteoporosis Aromatase Aromatase Aromatase Inhibitors Contraceptives, Oral Contraceptives, Oral Drug Therapy, Combination Endometriosis Endometriosis Endometriosis Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Osteoporosis Pain

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (6)

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License: CC0 · commercial use OK