[Treatment of endometriosis by aromatase inhibitors: efficacy and side effects]

Racine AC, A.-C. Racine, E. Legrand, Legrand E, Érick Legrand, Lefebvre-Lacoeuille C, C. Lefebvre-Lacœuille, C. Lefebvre-Lacoeuille, Hoppe E, E Hoppe, E. Hoppé, Catala L, L. Catala, L Sentilhes, Loı̈c Sentilhes, Sentilhes L, Descamps P, P. Descamps
Gynecologie, obstetrique & fertilite · 2010 · vol. 38(5) , pp. 318–323 · doi:10.1016/j.gyobfe.2010.03.005 · PMID:20430665 · W2154599588
Systematic review / meta-analysis OA: closed CC0 ⤵ 6 in-corpus citations
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This paper reviews the therapeutic efficacy and bone-related consequences of using aromatase inhibitors to treat endometriosis.

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Abstract

The recent demonstration that aromatase is expressed at higher levels in endometriosis implants than in normal endometrium has led to pilot studies using inhibitor aromatasis in patients with endometriosis. We conducted a systematic review of the literature and studied the efficacy of aromatase inhibitors on endometriosis. There were seventeen studies (case reports/series) evaluating outcomes of aromatase inhibitors. Studies suggest that aromatase inhibitors alone or co-administered with progestins, oral contraceptives or gonadotrophin releasing hormone (GnRH) agonist could reduce pain and endometriosis. There is only one randomized controlled trial comparing aromatase inhibitor+GnRH agonist and GnRH agonist and one study with eighty patients. Side-effects profiles of aromatase inhibitor regimens are favorable; it does not appear a significant bone loss. Aromatase inhibitors seem to have a promising effect on endometriosis but randomized controlled trials are needed to prove their effects and their safety.

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Condition tags

endometriosis

MeSH descriptors

Aromatase Inhibitors Aromatase Inhibitors Endometriosis Osteoporosis Aromatase Aromatase Aromatase Aromatase Inhibitors Aromatase Inhibitors Contraceptives, Oral Contraceptives, Oral Contraceptives, Oral Drug Therapy, Combination Drug Therapy, Combination Endometriosis Endometriosis Endometriosis Endometriosis Female Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (43)

Cited by (7)

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License: CC0 · commercial use OK