Expression of aromatase (P450 aromatase/CYP19) in peritoneal and ovarian endometriotic tissues and deep endometriotic (adenomyotic) nodules of the rectovaginal septum
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This study investigated the presence and levels of aromatase in peritoneal and ovarian endometriotic tissues, as well as deep endometriotic nodules of the rectovaginal septum.
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Abstract
We found, by reverse transcription--real time--polymerase chain reaction, that the expression of aromatase (CYP19) in ovarian, peritoneal endometriosis, and deep endometriotic nodules is significantly different, which strengthens the theory of three distinct clinical entities. Compared with peritoneal endometriosis, ovarian endometriosis exhibits an 8-fold higher expression of aromatase, which suggests that aromatase inhibitors may be particularly active in this form of endometriosis.
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- Effects of cisplatin and letrozole on surgically induced endometriosis and comparison of the two medications in a rat model 2016
- Molecular Biology of Endometriosis 2016
- Role of Aromatase Inhibitors in the Treatment of Endometriosis 2014
- Endometriosis 2013
- Functional MicroRNA Involved in Endometriosis 2011
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- The emerging use of aromatase inhibitors for endometriosis treatment 2011
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- Endometriosis 2009
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- Estrogen metabolism and action in endometriosis 2009
- Selective Estrogen-Receptor Modulators and Aromatase Inhibitors: Promising New Medical Therapies for Endometriosis? 2007
- Vascular density and distribution of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) are significantly higher in patients with deeply infiltrating endometriosis affecting the rectum 2007
- Expression of Aromatase and Estrogen Sulfotransferase in Eutopic and Ectopic Endometrium: Evidence for Unbalanced Estradiol Production in Endometriosis 2007
- Untersuchungen zur Expression und endokrinen Regulation der epidermal growth factor receptor Familie in endometriotischen Läsionen 2007
- Inhibition of steroid sulphatase activity in endometriotic implants by 667 COUMATE: a potential new therapy 2007
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- Image analysis measurements of the microvascularisation in endometrium, superficial and deep endometriotic tissues 2006
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