Expression of aromatase (P450 aromatase/CYP19) in peritoneal and ovarian endometriotic tissues and deep endometriotic (adenomyotic) nodules of the rectovaginal septum
Non-randomised trial
OA: closed
CC0
⤵ 30 in-corpus citations
AI-generated summary
This study investigated the presence and levels of aromatase in peritoneal and ovarian endometriotic tissues, as well as deep endometriotic nodules of the rectovaginal septum.
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Abstract
We found, by reverse transcription--real time--polymerase chain reaction, that the expression of aromatase (CYP19) in ovarian, peritoneal endometriosis, and deep endometriotic nodules is significantly different, which strengthens the theory of three distinct clinical entities. Compared with peritoneal endometriosis, ovarian endometriosis exhibits an 8-fold higher expression of aromatase, which suggests that aromatase inhibitors may be particularly active in this form of endometriosis.
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References (10)
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- New medical treatments for endometriosis via openalex
- Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities via openalex
- W6675112554 via openalex
- W2099423538 via openalex
- W6656356435 via openalex
- W1754070801 via openalex
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- A Preliminary Investigation of the Roles of Endometrial Cells in Endometriosis Development via In Vitro and In Vivo Analyses 2024
- New biomarkers in endometriosis 2019
- Investigational Medical Therapies for Endometriosis: Current Data and Future Trends 2017
- Polychlorinated biphenyls and its potential role in endometriosis 2017
- Molecular Biology of Endometriosis 2016
- Effects of cisplatin and letrozole on surgically induced endometriosis and comparison of the two medications in a rat model 2016
- Role of Aromatase Inhibitors in the Treatment of Endometriosis 2014
- Endometriosis 2013
- Functional microRNA involved in endometriosis 2011
- Estrogen biosynthesis and signaling in endometriosis 2011
- The emerging use of aromatase inhibitors for endometriosis treatment 2011
- Are aromatase inhibitors effective in endometriosis treatment? 2011
- Endometriosis does not Alter Aromatase Gene Expression (CYP19A1) in Mural Lutein-granulosa Cells of Women Undergoing Assisted Reproduction Techniques – a Pilot Study 2011
- Pathophysiological factors and genetic association in endometriosis 2011
- Molecular profiling of human endometrium and endometriosis 2010
- Expression of aromatase in endometiosis and its relation to clinical laboratory and surgical parameters 2010
- [Treatment of endometriosis by aromatase inhibitors: efficacy and side effects] 2010
- Estrogen metabolism and action in endometriosis 2009
- Absence of aromatase protein and mRNA expression in endometriosis 2009
- Endometriosis 2009
- Expressão do gene da aromatase (CYP19A1) nas células da granulosa murais luteinizadas de mulheres com endometriose submetidas a técnicas de reprodução assistida 2009
- Endometriosis 2009
- Selective estrogen-receptor modulators and aromatase inhibitors: promising new medical therapies for endometriosis? 2007
- Vascular density and distribution of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) are significantly higher in patients with deeply infiltrating endometriosis affecting the rectum 2007
- Expression of aromatase and estrogen sulfotransferase in eutopic and ectopic endometrium: evidence for unbalanced estradiol production in endometriosis 2007
- Untersuchungen zur Expression und endokrinen Regulation der epidermal growth factor receptor Familie in endometriotischen Läsionen 2007
- Inhibition of steroid sulphatase activity in endometriotic implants by 667 COUMATE: a potential new therapy 2007
- Aromatase expression in endometriotic tissues and its relationship to clinical and analytical findings 2007
- Image analysis measurements of the microvascularisation in endometrium, superficial and deep endometriotic tissues 2006
Source provenance
- europepmc
- last seen: 2026-10-12T06:17:10.165071+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:03:44.483075+00:00
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