Hormonal and biochemical changes during treatment of endometriosis with the luteinizing hormone-releasing hormone (LH-RH) agonist [D-Trp6,des-Gly-NH210]LH-RH ethylamide

Dupont A, André Dupont, A Dupont, Dupont P, P Dupont, Pierre Dupont, A Belanger, Alain Bélanger, Belanger A, Mailoux J, Jacques Mailoux, J Mailoux, Cusan L, L Cusan, Léonello Cusan, Labrie F, Fernand Labrie, F Labrie
Fertility and Sterility · 1990 · vol. 54(2) , pp. 227–232 · doi:10.1016/s0015-0282(16)53694-2 · PMID:2199228 · W2399593562
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This study investigated hormonal and biochemical alterations in women with endometriosis undergoing treatment with the LH-RH agonist [D-Trp6, des-Gly-NH210]LH-RH ethylamide.

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Abstract

The effect of medical oophorectomy induced by treatment with the luteinizing hormone-releasing hormone (LH-RH) agonist [D-Trp6,des-Gly-NH2(10)]LH-RH ethylamide was studied in 34 patients with laparoscopically proven endometriosis. Tamoxifen was administered during the 1st month of therapy to prevent flare-up of the disease during the estrogen surge. Fifteen women had a decrease of their laparoscopy scores translated into an improvement in the stage of disease, whereas in 12 others, the decrease in their scores was not enough to allow a change of disease stage. The 2nd laparoscopy was not performed in 7 women. Medical oophorectomy, after daily injection of the LH-RH agonist (LH-RH-a), was accompanied by low levels of circulating estradiol. The serum concentration of all delta 4-3-ketosteroids was significantly decreased during medical oophorectomy, whereas the level of circulating delta 5-3 beta-hydroxysteroids was not altered except for pregnenolone. The present data indicate that medical oophorectomy induced by an LH-RH-a in association with tamoxifen is a very efficient and well tolerated therapy in endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Adrenal Cortex Hormones Endometriosis Gonadal Steroid Hormones Gonadotropin-Releasing Hormone Triptorelin Pamoate Triptorelin Pamoate Adrenal Cortex Hormones Adult Endometriosis Endometriosis Endometriosis Female Gonadal Steroid Hormones Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Osmolar Concentration

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