Interval of Injections of Intramuscular Depot Medroxyprogesterone Acetate in the Long-Term Treatment of Endometriosis-Associated Pain: A Randomized Comparative Trial

Sopon Cheewadhanaraks, Krantarat Peeyananjarassri, Chainarong Choksuchat, Kriengsak Dhanaworavibul, Thanapan Choobun, Sathana Bunyapipat
Gynecologic and obstetric investigation · 2009 · vol. 68(2) , pp. 116–121 · doi:10.1159/000226090 · PMID:19556801 · W2057945300
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This randomized trial found no significant difference in patient satisfaction between monthly and every-three-month injections of depot medroxyprogesterone acetate for endometriosis pain.

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Abstract

AIM: To determine the optimal interval of injections of intramuscular depot medroxyprogesterone acetate 150 mg in the long-term treatment of endometriosis-associated pain. METHOD: 112 patients with symptomatic endometriosis were randomized to receive either injections every month for 6 months, then every 3 months for a total of 15 months or injections every 3 months for 15 months. The primary outcome measure was patients' satisfaction. RESULT: At months 3, 6, 9, 12 and 15 of the treatment phase, there was no statistically significant difference of percentages of patients with satisfaction between the two regimens (85.7 vs. 76.8%, 76.8 vs. 73.2%, 66.1 vs. 58.9%, 60.7 vs. 55.4%, 60.7 vs. 55.4%, respectively). CONCLUSION: The optimal interval of injections of depot medroxyprogesterone acetate 150 mg is every 3 months.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Medroxyprogesterone Acetate Pain Adult Delayed-Action Preparations Drug Administration Schedule Endometriosis Endometriosis Endometriosis Female Humans Injections, Intramuscular Medroxyprogesterone Acetate Medroxyprogesterone Acetate Pain Pain Patient Satisfaction Patient Selection Premenopause Time Factors

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