Interval of injections of intramuscular depot medroxyprogesterone acetate in the long-term treatment of endometriosis-associated pain: a randomized comparative trial

Sopon Cheewadhanaraks, Cheewadhanaraks S, Krantarat Peeyananjarassri, Peeyananjarassri K, Choksuchat C, Chainarong Choksuchat, Kriengsak Dhanaworavibul, Thanapan Choobun, Choobun T, Sathana Bunyapipat, Bunyapipat S
Gynecologic and obstetric investigation · 2009 · vol. 68(2) , pp. 116–121 · doi:10.1159/000226090 · PMID:19556801 · W2057945300
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This randomized trial found no significant difference in patient satisfaction between monthly and every-three-month injections of depot medroxyprogesterone acetate for endometriosis pain.

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Abstract

AIM: To determine the optimal interval of injections of intramuscular depot medroxyprogesterone acetate 150 mg in the long-term treatment of endometriosis-associated pain. METHOD: 112 patients with symptomatic endometriosis were randomized to receive either injections every month for 6 months, then every 3 months for a total of 15 months or injections every 3 months for 15 months. The primary outcome measure was patients' satisfaction. RESULT: At months 3, 6, 9, 12 and 15 of the treatment phase, there was no statistically significant difference of percentages of patients with satisfaction between the two regimens (85.7 vs. 76.8%, 76.8 vs. 73.2%, 66.1 vs. 58.9%, 60.7 vs. 55.4%, 60.7 vs. 55.4%, respectively). CONCLUSION: The optimal interval of injections of depot medroxyprogesterone acetate 150 mg is every 3 months.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Medroxyprogesterone Acetate Pain Adult Adult Delayed-Action Preparations Delayed-Action Preparations Drug Administration Schedule Drug Administration Schedule Endometriosis Endometriosis Endometriosis Endometriosis Female Female Humans Humans Injections, Intramuscular Injections, Intramuscular Medroxyprogesterone Acetate

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (24)

Cited by (6)

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