Scientific reports

Recurrent implantation failure (RIF), a important contributor to infertility in assisted reproductive technologies, is believed to be primarily to abnormal endometrial decidualization. However, its related molecular mechanisms are still inc…

There is significant interest in the development of comprehensive strategies to combat obesity. One such approach involves the combination of exercise training with pharmacological interventions. Recently, the injection of adenosine (Ade) h…

Endometriosis is a chronic, estrogen-dependent inflammatory disease that causes debilitating pain and significantly impairs quality of life. Due to its anti-inflammatory and immunomodulatory properties, vitamin D has been proposed as a pote…

Endometriosis is a chronic, multifactorial disorder. Reactive oxygen species (ROS) and oxidative stress (OS) contribute to the development of endometriosis by affecting apoptosis-related genes in granulosa cells. N-acetylcysteine (NAC) is a…

Adnexal cystic torsion is a gynecological emergency that requires prompt and accurate diagnosis followed by immediate surgical intervention to preserve ovarian function. Although ultrasound or computed tomography (CT) are commonly employed,…

Hereditary breast and ovarian cancer syndrome (HBOC) is principally caused by germline mutations in BRCA1 and BRCA2. However, most women with HBOC are undiagnosed, and some patients meeting clinical criteria for HBOC will have no identifiab…

Abdominal cytoreductive surgery due to advanced-stage ovarian cancer (OC) often requires extensive fluid administration to stabilize hemodynamic conditions. Recently, systemic changes in the expression profile of Angiopoietin (ANG)/TIE axis…

Recurrent implantation failure (RIF) remains a major challenge in assisted reproductive technology, and the molecular mechanisms underlying endometrial receptivity are incompletely understood. This study aimed to comprehensively characteriz…

Chronic endometritis is linked to recurrent pregnancy loss and in vitro fertilization failure. The responsiveness to antibiotics suggests a bacterial cause, however endometriosis could also play a role. This study aimed to compare treatment…

Premature ovarian insufficiency (POI) is a reproductive endocrine disorder characterized by amenorrhea, hypergonadotropism, and hypoestrogenism before age 40. This study investigated the association of serum Chemerin, follicle stimulating h…

Per- and polyfluoroalkyl substances (PFAS) have been previously associated with polycystic ovary syndrome (PCOS). However, the health effects of emerging PFAS alternatives on PCOS remain unclear. This study aims to examine the associations …

This study aimed to investigate the association between sonographic features of adenomyosis defined by the revised MUSA criteria and pregnancy outcomes in women undergoing in vitro fertilization (IVF) and embryo transfer (ET). All autologou…

Endometriosis (ENDO) is an estrogen-dependent chronic gynaecological manifestation of uterine fragments attached outside of the uterus, accompanied by debilitating chronic pelvic pain. The evoked assays often employed fail to capture the su…

Cannabidiol (CBD) has potential for treating obesity-induced inflammation; thus, we studied the influence of CBD on the accumulation of lipid precursors of inflammation, the, enzymes, and cytokine levels in the subcutaneous (SAT) and viscer…

Neonatal uterine bleeding (NUB) has been hypothesized as a relatively common early-life event potentially linked to the later development of endometriosis through retrograde menstruation. However, its true prevalence and biological nature r…

Uterine fibroids (UFs) and endometrial polyps (EPs) are common benign gynecological conditions with distinct anatomical origins. However, their molecular impact on endometrial function remains poorly understood. This study aimed to descript…

The objective of this study is to analyze and compare the effects of Mat Pilates and Reformer Pilates methods on pain intensity, menstrual pain and symptoms, depression, fatigue, and sleep quality in women with dysmenorrhea. This study incl…

There is limited research on how different treatment modalities relate to holistic recovery outcomes for alcohol or other drug-related use disorders among college students. Using national data from the American College Health Association-Na…

This study utilized the Surveillance, Epidemiology, and End Results (SEER) database to identify clinicopathological prognostic factors and develop a prognostic nomogram for predicting 1-, 3-, and 5-year overall survival (OS) in patients wit…

Endometrial carcinoma, a prevailing malignancy of the female reproductive system, exhibits escalating incidence and a trend towards early onset. Hormone therapy serves as a primary choice for fertility preservation and is also considered fo…

Endometriosis is a chronic, estrogen-dependent inflammatory disease sustained by aberrant angiogenesis and progressive fibrosis. We evaluated the therapeutic efficacy of human dental pulp-derived mesenchymal stem cells (DP-MSCs) in a surgic…

Tensin1 (TNS1) is a key component of focal and fibrillar adhesions, mediating fibrillogenesis, as well as the transduction of mechanical cues and adhesive signaling. To enable further TNS1 characterization, we have developed a novel transge…

This study aimed to develop and validate a clinical prediction model for the success of the focused ultrasound ablation system (FUAS) in treating adenomyosis. A retrospective analysis was conducted on 250 patients from Qingdao Women and Chi…

Infertility affects 17.5% of reproductive-age couples and represents a global health challenge with a complex etiology. While nutritional status and diet are recognized as modifiable factors, evidence in specialized clinical settings remain…

To date, only a few studies have examined the relationship between dietary patterns and premenstrual syndrome (PMS), and these have been limited to Asian populations with inconclusive results, while studies in European populations are lacki…