Scientific reports

Treatment expectations are central to psychotherapy outcomes but are typically assessed as a unidimensional construct focusing on anticipated improvement. This study investigated whether expectations of improvement, worsening, and side effe…

Double-negative T cells (DNTs; CD3+CD4-CD8-) have been implicated in immune regulation in autoimmune settings, but their relevance to reproductive tissue immune balance and inflammation-associated infertility remains unclear. Here, we defin…

Apoptosis plays a paramount role in endometriosis pathogenesis. This process may be disrupted in endometrial stromal cells (ESCs) of women with endometriosis, causing them to continue developing in ectopic locations. This study investigates…

To investigate the efficacy of different pretreatment protocols for women with endometriosis undergoing IVF. We systematically searched the Cochrane Library, PubMed, Medline, and Embase from inception to April 30, 2025, to identify randomiz…

Primary dysmenorrhea is painful menstruation in the absence of pelvic pathology, whereas secondary dysmenorrhea is menstrual pain attributable to an underlying pelvic disease (e.g., endometriosis). Nonsteroidal anti-inflammatory drugs (NSAI…

Despite fertility treatments are a stressful journey, there remains a lack of studies assessing how stress is affecting endometrial function in infertility. This prospective cohort study, including 84 endometrial biopsies, aims to elucidate…

Ovarian cancer poses a significant clinical challenge due to its asymptomatic onset and poor prognosis, highlighting the critical need for effective early detection strategies. This study developed a framework that integrates serum proteomi…

Endometriosis is a disease characterized by fibrosis and adhesions. There are still no treatment methods targeting these conditions. One reason for this is the lack of useful animal models to investigate the mechanisms of fibrosis and adhes…

Polycystic ovary syndrome (PCOS) is a major risk factor for ovarian hyperstimulation syndrome (OHSS) during controlled ovarian stimulation (COS). Oxidative stress and inflammation, mediated by the advanced glycation end products (AGE)-recep…

Dysmenorrhea is often linked to uterine inflammation, but the additional factors and pathways that contribute to its pathophysiology remain poorly understood. Given growing evidence linking endoplasmic reticulum (ER) stress to inflammation …

Ovarian cancer is classified as a female malignancy commonly known as a silent killer with no early detection symptoms. Extracellular matrix protein 1 (ECM1) is associated with the Epithelial-mesenchymal transition (EMT) and metastasis proc…

Estrogen is a key regulatory hormone that maintains metabolic and gut homeostasis by modulating immune responses, microbial composition, and energy balance. However, estrogen deficiency is strongly associated with gut associated metabolic d…

Endometriosis is a chronic and debilitating gynecological disorder affecting approximately 10% of women of reproductive age worldwide (190 million), often leading to chronic pain, infertility, and considerable economic burden. Despite being…

Background: Sexually transmitted infections (STIs) such as Treponema pallidum (T. pallidum), Hepatitis B and C viruses (HBV and HCV), and Human Papillomavirus (HPV) are significant global health threats. High-risk HPV (HR-HPV), particularly…

Endometriosis is a chronic inflammatory disease characterized by ectopic endometrial tissue growth, causing pain and infertility. Diagnosis is often delayed due to reliance on imaging and invasive methods, highlighting the need for non-inva…

Previously, we identified water-soluble compounds with membrane progestin receptor α (mPRα)-binding activity from the marine algae Padina arborescens. The compounds inhibited fish oocyte maturation. These compounds are potentially novel ant…

Endometriosis is a chronic estrogen-dependent disorder affecting up to 10% of women of reproductive age, and the absence of reliable noninvasive diagnostic tools contributes to delayed diagnosis and disease progression. To identify potentia…

Postoperative adhesions (PA) remain an untreatable complication of abdominal surgery. In this study, we analyzed the role of interleukin-8 (IL-8) in the formation of PA using human cells in vitro and cynomolgus monkeys in vivo, as rodents l…

This study was designed to evaluate the beneficial roles of the MSOME technique over × 400 magnification in terms of pregnancy outcomes, Live birth rate (LBR) and miscarriage rate in patients with severe teratozoospermia. This trial was con…

Aberrant expression levels of miR-760 and miR-1973 were observed in different solid tumors; however, their expression levels in breast cancer (BC) remain unclear. This study aimed to evaluate their expression levels, assess their relationsh…

The link between endometriosis and other medical conditions is gaining attention. Such insights could enhance clinical approaches to manage the disease and potentially reveal new, unrecognized mechanisms of its development. The aim of this …

Per- and polyfluoroalkyl substances (PFAS) are a class of anthropogenic organic compounds ubiquitous in the environment. Growing evidence has underscored these associated health risks. Diminished ovarian reserve (DOR), which is characterize…

Finding interesting phenomena is the core of scientific discovery, but the notion of interestingness is vaguely defined and heavily reliant on manual judgment. We present InterFeat, an integrative pipeline for automating the discovery and r…

Daily activities, work, and health are closely intertwined. We closely followed 45 participants aged 50-66 years working across different sectors in a year-long study, who completed a range of baseline, weekly, and monthly Participant Repor…

Oxytocin is commonly administered during caesarean delivery (CD) to prevent postpartum haemorrhage as an initial bolus followed by a maintenance dose. Nearly half of perinatal centres in Japan utilise intramyometrial (IMY) oxytocin. IMY oxy…