A preliminary evaluation of influence of body mass index on in vitro fertilization outcome in non-obese endometriosis patients

Eliana Garalejić, Eliana Garalejic, Biljana Arsic, Biljana Arsić, Jovana Radakovic, Jovana Radaković, Dragana Bojovic Jovic, Dragana Lekic, Dragana Lekić, Biljana Macanovic, Ivan Soldatovic, Ivan Soldatović, Milan Perović
BMC women's health · 2017 · vol. 17(1) , pp. 112 · doi:10.1186/s12905-017-0457-0 · PMID:29145852 · W2768539690
article OA: gold CC0 ⤵ 9 in-corpus citations
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This study found that higher BMI did not negatively impact IVF outcomes in non-obese women with endometriosis, contrary to general findings in infertile populations.

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Abstract

BACKGROUND/AIMS: Obese and overweight women experience a lower probability for pregnancy after IVF. However, despite the increasing prevalence of obesity, the large majority of infertile women are non-obese. One of the most common indications for IVF is endometriosis. Thought-provoking inverse correlation has been established between BMI and endometriosis. Lower BMI is a risk factor for development of endometriosis and a predictive factor for severe endometriosis. Since severe endometriosis carries lower reproductive chances, even after IVF, we preliminary tested a hypothesis that higher BMI among non-obese endometriosis patients improves IVF outcomes. METHODS: Preliminary retrospective observational cross-sectional study was performed in women with endometriosis as a sole infertility cause who underwent IVF. During analyzed period we performed 2782 IVF procedures. In order to achieve highly homogenous study sample and to eliminate almost all confound factors that could lead to bias, we implemented strict study criteria. The number of eligible subjects was 156 and they were divided into underweight, normal weight and overweight groups. Primary outcomes were number of retrieved oocytes, good quality oocytes, embryos, and the rates of biochemical, clinical and ongoing pregnancies. For group comparisons, we used parametric test, analysis of variance, and non-parametric tests (Kruskal-Wallis test, Chi-square test). Logistic regression and General linear model was used to assess correlation between BMI and dependent variables (outcome and stimulation duration) when adjusted for age. RESULTS: Endometriosis as a single infertility factor among IVF couples had prevalence of 5.61%. Underweight women accounted for 10.26%, normal weight 71.15% and overweight 18.59% of study population. Significant differences were not found in number of retrieved oocytes (p = 0.880), good quality oocytes (p = 0.476), obtained embryos (p = 0.706), and biochemical (p = 0.298), clinical (p = 0.770) and ongoing (p = 0.822) pregnancy rates between study groups. CONCLUSION: Although preliminary results do not support our hypothesis, increase in BMI did not adversely affect the outcome of IVF in non-obese endometriosis patients, which is in contrast to literature data as regards general population of infertile women undergoing IVF. Prospective studies with large number of patients with endometriosis or prospective case-control studies should address these issues and provide more comprehensive counseling of infertile endometriosis patients regarding achievement of optimal BMI prior to IVF with the intention of achievement higher pregnancy rates.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Body Mass Index Endometriosis Fertilization in Vitro Infertility, Female Infertility, Female Pregnancy Rate Adult Case-Control Studies Cross-Sectional Studies Endometriosis Female Humans Infertility, Female Pregnancy Prospective Studies Retrospective Studies

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