Expression of interleukin‐6 and monocyte chemoattractant protein‐1 by peritoneal sub‐mesothelial cells during abdominal operations

Janik Riese, Gerald Niedobitek, Renate Lisner, Andreas Jung, Werner Hohenberger, W. Haupt
In: The Journal of Pathology · 2003 · vol. 202(1) , pp. 34–40 · doi:10.1002/path.1455 · PMID:14694519 · W2000478362
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Peritoneal endothelial cells produce increased IL-6, while endothelial cells, smooth muscle cells, fibroblasts, and some macrophages and mesothelial cells produce MCP-1 following abdominal surgery.

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Abstract

Cytokines and chemokines including interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) are secreted in response to major abdominal operations. The aim of this study was to identify the peritoneal cells that produce IL-6 and MCP-1. Samples of peritoneal tissue were taken from patients at the beginning and end of major abdominal operations. The samples were incubated in culture medium on microtitre plates for 5 h. The concentrations of IL-6 and MCP-1 were measured in culture supernatants by enzyme-linked immunosorbent assay (ELISA). In paraffin sections, cells that expressed IL-6 or MCP-1 were identified by combined in situ hybridization and immunohistochemistry. Antibodies against CD68, CD34, actin, and calretinin were included in these experiments. The median production of IL-6 increased significantly from 6256 pg/ml at the start of the operation to 20,000 pg/ml at the end. Production of MCP-1 rose from 7700 pg/ml to 11,820 pg/ml. IL-6 mRNA was mainly confined to endothelial cells. MCP-1 was expressed by a broader range of cells, consisting of actin-positive smooth muscle cells and endothelial cells, fibroblast-like cells, as well as occasional macrophages and mesothelial cells. Peritoneal endothelial cells contribute to the transient increase in concentrations of IL-6 in the circulation after surgical trauma. Recruitment of monocytes to the site of the trauma seems to be mainly effected by actin-positive smooth muscle cells and endothelial cells.

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