FR 167653, a p38 mitogen-activated protein kinase inhibitor, suppresses the development of endometriosis in a murine model

Osamu Yoshino, Yoshino O, Yutaka Osuga, Osuga Y, Kaori Koga, Yasushi Hirota, Tetsuya Hirata, Xie Ruimeng, Ruimeng X, Li Na, Na L, Tetsu Yano, Yano T, Osamu Tsutsumi, Tsutsumi O, Taketani Y, Yuji Taketani
Journal of Reproductive Immunology · 2006 · vol. 72(1-2) , pp. 85–93 · doi:10.1016/j.jri.2005.02.004 · PMID:16890996 · W2021391025
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FR 167653, a p38 mitogen-activated protein kinase inhibitor, was found to suppress endometriosis development in a murine model.

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Abstract

In various cells including endometriotic cells, p38 mitogen-activated protein kinase (MAPK) plays essential roles for inflammation, an etiological factor for endometriosis. We evaluated the effect of FR 167653, a p38 MAPK inhibitor, on the development of endometriosis using a murine model. As an endometriosis model, estradiol-treated ovariectomized BALB/c mice were injected intraperitoneally with endometrial fragments of the syngenic donor mice. The animals were injected with either 30mg/kg FR 167653 or only vehicle (control) s.c. twice a day, starting 2 days before endometrial injection. Three weeks later, the peritoneal fluids and the developed endometriotic lesions were collected. Both the weight of all the endometriotic lesions per mouse and the concentrations of interleukin-6 and monocyte chemoattractant protein-1 in the peritoneal fluid were significantly lower in the FR 167653-treated mice than in the control mice. These findings suggest that FR 167653 may inhibit the development of endometriosis possibly by suppressing peritoneal inflammatory status.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis p38 Mitogen-Activated Protein Kinases Protein Kinase Inhibitors Pyrazoles Pyridines Uterine Diseases Animals Chemokine CCL2 Chemokine CCL2 Chemokine CCL2 Chemokine CCL2 Disease Models, Animal Endometriosis Endometriosis Female Interleukin-6 Interleukin-6 Interleukin-6 Interleukin-6 Mice

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