Atorvastatin causes regression of endometriotic implants in a rat model

Bülent Yılmaz, Yilmaz B, Bulent Yilmaz, Mustafa Özat, Mustafa Ozat, Ozat M, Sevtap Kilic, Kilic S, Sevtap Kılıç, Gungor T, Tayfun Gungor, Aksoy Y, Yasemin Aksoy, Nese Lordlar, Lordlar N, Necdet Süt, Necdet Sut, Sut N, Orhan Aksakal, Aksakal O
Reproductive biomedicine online · 2009 · vol. 20(2) , pp. 291–299 · doi:10.1016/j.rbmo.2009.11.004 · PMID:20113969 · W2040325288
article OA: bronze CC0 ⤵ 39 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

In a rat model, atorvastatin treatment effectively reduced the size and number of surgically induced endometriotic implants.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Endometriotic implants were induced surgically in female Wistar albino rats, which were randomly divided into three groups. The rats in group I (n=10) and group II (n=9) were given 2.5 mg/kg/day intraperitoneal and oral atorvastatin, respectively, for 28 days. Group III (n=9) was given no medication (control). The mean volume and weight of explants in group I were significantly lower (both P < 0.05) compared with group III. Histopathological score of the implants was significantly lower in groups I and II, when compared with group III (P < 0.01 and P < 0.05, respectively). There were significant reductions in explant concentrations of vascular endothelial growth factor and matrix metalloproteinase 9 in group I (P < 0.01 and P < 0.001, respectively) and group II (both P < 0.01) compared with group III while staining due to tissue inhibitor of metalloproteinase 2 was significantly higher in group I (P < 0.01) and group II (P < 0.01) compared with group III. Moreover, explant concentration of superoxide dismutase was significantly increased in groups I and II compared with group III (both P < 0.05). In conclusion, atorvastatin causes significant regression of endometriotic implants in rats. Moreover, intraperitoneal atorvastatin seems to be more effective than oral atorvastatin.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Antioxidants Endometriosis Heptanoic Acids Pyrroles Animals Antioxidants Antioxidants Atorvastatin Disease Models, Animal Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Heptanoic Acids Heptanoic Acids Pyrroles Pyrroles Rats

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (57)

Cited by (39)

Source provenance

europepmc
last seen: 2026-07-26T06:08:39.051465+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:17:18.915199+00:00
License: CC0 · commercial use OK