Serum MicroRNA Biomarkers Regulated by Simvastatin in a Primate Model of Endometriosis

Emine Çoşar, Emine Cosar, Ramanaiah Mamillapalli, Irene Moridi, Antoni Duleba, Antoni J. Dulęba, Hugh S Taylor
Reproductive sciences (Thousand Oaks, Calif.) · 2018 · vol. 26(10) , pp. 1343–1350 · doi:10.1177/1933719118765971 · PMID:29587611 · PMC6949973 · W2794784577
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

Simvastatin treatment in a baboon endometriosis model decreased miR-150-5p and miR-451a and increased miR-3613-5p levels, normalizing them towards control expression.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This study evaluated whether previously identified circulating serum microRNAs that are dysregulated in human endometriosis could be measured in a nonhuman primate model and whether they change with simvastatin treatment. Endometriosis was induced in 16 baboons, randomized to simvastatin or vehicle for 90 days, and serum levels of 9 target miRNAs were quantified by qRT-PCR after 3 months; the paper reports that miR-150-5p and miR-451a decreased, while miR-3613-5p increased in simvastatin-treated animals compared with untreated endometriosis, and that these patterns paralleled human findings and returned toward control-like expression. A key caveat is that this was a pilot study with a limited sample size and focused on a predefined miRNA panel rather than a broader discovery approach. This paper is centrally about endometriosis — it uses a baboon endometriosis model to test serum microRNA biomarkers and how simvastatin alters their expression.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis MicroRNAs Simvastatin Animals Biomarkers Biomarkers Disease Models, Animal Endometriosis Female MicroRNAs Papio Simvastatin

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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