Simvastatin inhibits the proliferation and the contractility of human endometriotic stromal cells: a promising agent for the treatment of endometriosis

Nasu K, Kaei Nasu, Akitoshi Yuge, Yuge A, Akitoshi Tsuno, Tsuno A, Hisashi Narahara, Narahara H
Fertility and sterility · 2009 · vol. 92(6) , pp. 2097–2099 · doi:10.1016/j.fertnstert.2009.06.055 · PMID:19643402 · W2129274131
article OA: bronze CC0 ⤵ 38 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Simvastatin was investigated for its effects on human endometriotic stromal cells, revealing its capacity to inhibit both cell proliferation and contractility.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Simvastatin significantly inhibited the proliferation of endometriotic stromal cells, attenuated the collagen gel contraction mediated by these cells, and suppressed endometriotic stromal cell attachment to collagen fibers. Simvastatin is considered to be a promising agent for the treatment of endometriosis-associated fibrosis, which is among the major pathologies caused by endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Simvastatin Stromal Cells Stromal Cells Cell Division Cell Division Cells, Cultured Collagen Collagen Endometriosis Female Fibrosis Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Hydroxymethylglutaryl-CoA Reductase Inhibitors In Vitro Techniques Simvastatin Stromal Cells Stromal Cells

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (23)

Cited by (39)

Source provenance

europepmc
last seen: 2026-08-17T06:11:01.428247+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:13:59.677786+00:00
License: CC0 · commercial use OK