Ramanaiah Mamillapalli

Endometriosis is a chronic systemic disease affecting ∼10-15% of women of reproductive age, often resulting in chronic pelvic pain and infertility. Despite its high prevalence, diagnosis is frequently delayed. tRNA-derived fragments (tRFs) …

Endometriosis is an inflammatory chronic gynecological condition that affects 10-15% of reproductive-age women which causes pelvic pain and infertility. The disease is characterized by the growth of endometrial tissue outside the uterine ca…

Endometriosis is a multifaceted disease, causing debilitating pelvic pain in some patients, while being completely asymptomatic in others. The pathophysiology of endometriosis pain is not well understood and poorly correlated to stage. We h…

OBJECTIVE: Endometriosis is a heterogeneous, estrogen-dependent inflammatory disorder that affects up to 15% of reproductive age women. Progestin-based therapies are the most commonly prescribed initial treatment; however, approximately one…

Endometriosis is a chronic, systemic gynecological disorder that affects 190 million women worldwide. Current treatments consist of hormonal suppression and surgical excision; however, both have considerable side effects and a high risk of …

Adenomyosis is a common gynecological disorder characterized by the presence of endometrial tissue in the myometrium, causing chronic pelvic pain and abnormal bleeding. Although dysregulated microRNAs (miRNAs) in stromal cells of adenomyosi…

BACKGROUND: Endometriosis is a common gynecological disorder causing pelvic pain and infertility. While generally attributed to peritoneal implants of endometrium derived from retrograde menstruation, the contribution of cells from the circ…

Supplementary fig. 1: Showing HOXA11-AS-pcDNA3.1(+) plasmid map (7039 bp) containing HOXA11-AS gene (1640 bp)

Supplementary fig. 1: Showing HOXA11-AS-pcDNA3.1(+) plasmid map (7039 bp) containing HOXA11-AS gene (1640 bp)

Supplementary fig. 2: HOXA11-AS expression levels in COC and progestin subgroups. mRNA levels in ectopic lesions were determined by quantitative RT-qPCR from patients with endometriosis. HOXA11-AS mRNA levels were downregulated in endometri…

Supplementary fig. 2: HOXA11-AS expression levels in COC and progestin subgroups. mRNA levels in ectopic lesions were determined by quantitative RT-qPCR from patients with endometriosis. HOXA11-AS mRNA levels were downregulated in endometri…

Supplementary Material 3

Supplementary Material 3

OBJECTIVE: To determine if microRNAs that are altered in the circulation of women with endometriosis affect metabolic gene expression in hepatic cells. DESIGN: In vitro study. SUBJECTS: Deidentified tissue from women with endometriosis. …

Asherman Syndrome (AS) is caused by injury to the endometrium leading to uterine scarring, decreased menstruation and infertility; it typically occurs after surgical curettage of the uterus. AS is treated surgically albeit with limited succ…

BACKGROUND: Endometriosis is a gynecological disorder that affects 190 million reproductive age women worldwide. Laparoscopic surgery is considered the gold standard to diagnose the disease, creating a barrier to diagnosis and leading to lo…

Endometriosis is a gynecological inflammatory disorder characterized by the presence of endometrial tissue outside of the uterus. It affects 10-15% of reproductive aged women, causing pelvic pain and infertility. Existing treatments for end…

The human endometrium, a dynamic tissue that undergoes cyclical shedding, repair, regeneration, and remodeling, relies on progenitor stem cells for replenishment. Bone marrow-derived mesenchymal stem cells (BM-MSCs) also may play a crucial …

Abstract Objective To investigate the function of HOXA11-antisense long non-coding RNA (HOXA11-AS) in endometriosis treatment response. Methods Tissue samples (ectopic and eutopic endometrium) were obtained from surgically diagnosed subject…

Abstract Objective To investigate the function of HOXA11-antisense long non-coding RNA (HOXA11-AS) in endometriosis treatment response. Methods Tissue samples (ectopic and eutopic endometrium) were obtained from surgically diagnosed subject…

OBJECTIVE: To investigate the function of HOXA11-antisense long non-coding RNA (HOXA11-AS) in endometriosis treatment response. METHODS: Tissue samples (ectopic and eutopic endometrium) were obtained from surgically diagnosed subjects with…