Ramanaiah Mamillapalli

OBJECTIVE: Endometriosis is a heterogeneous, estrogen-dependent inflammatory disorder that affects up to 15% of reproductive age women. Progestin-based therapies are the most commonly prescribed initial treatment; however, approximately one…

Adenomyosis is a common gynecological disorder characterized by the presence of endometrial tissue in the myometrium, causing chronic pelvic pain and abnormal bleeding. Although dysregulated microRNAs (miRNAs) in stromal cells of adenomyosi…

BACKGROUND: Endometriosis is a common gynecological disorder causing pelvic pain and infertility. While generally attributed to peritoneal implants of endometrium derived from retrograde menstruation, the contribution of cells from the circ…

Supplementary fig. 1: Showing HOXA11-AS-pcDNA3.1(+) plasmid map (7039 bp) containing HOXA11-AS gene (1640 bp)

Supplementary fig. 1: Showing HOXA11-AS-pcDNA3.1(+) plasmid map (7039 bp) containing HOXA11-AS gene (1640 bp)

Supplementary fig. 2: HOXA11-AS expression levels in COC and progestin subgroups. mRNA levels in ectopic lesions were determined by quantitative RT-qPCR from patients with endometriosis. HOXA11-AS mRNA levels were downregulated in endometri…

Supplementary fig. 2: HOXA11-AS expression levels in COC and progestin subgroups. mRNA levels in ectopic lesions were determined by quantitative RT-qPCR from patients with endometriosis. HOXA11-AS mRNA levels were downregulated in endometri…

Supplementary Material 3

Supplementary Material 3

OBJECTIVE: To determine if microRNAs that are altered in the circulation of women with endometriosis affect metabolic gene expression in hepatic cells. DESIGN: In vitro study. SUBJECTS: Deidentified tissue from women with endometriosis. …

BACKGROUND: Endometriosis is a gynecological disorder that affects 190 million reproductive age women worldwide. Laparoscopic surgery is considered the gold standard to diagnose the disease, creating a barrier to diagnosis and leading to lo…

Endometriosis is a gynecological inflammatory disorder characterized by the presence of endometrial tissue outside of the uterus. It affects 10-15% of reproductive aged women, causing pelvic pain and infertility. Existing treatments for end…

The human endometrium, a dynamic tissue that undergoes cyclical shedding, repair, regeneration, and remodeling, relies on progenitor stem cells for replenishment. Bone marrow-derived mesenchymal stem cells (BM-MSCs) also may play a crucial …

OBJECTIVE: To investigate the function of HOXA11-antisense long non-coding RNA (HOXA11-AS) in endometriosis treatment response. METHODS: Tissue samples (ectopic and eutopic endometrium) were obtained from surgically diagnosed subjects with …

Abstract Objective To investigate the function of HOXA11-antisense long non-coding RNA (HOXA11-AS) in endometriosis treatment response. Methods Tissue samples (ectopic and eutopic endometrium) were obtained from surgically diagnosed subject…

Abstract Objective To investigate the function of HOXA11-antisense long non-coding RNA (HOXA11-AS) in endometriosis treatment response. Methods Tissue samples (ectopic and eutopic endometrium) were obtained from surgically diagnosed subject…

Endometriosis is a debilitating, chronic inflammatory disease affecting approximately 10% of reproductive-age women worldwide with no cure. While macrophages have been intrinsically linked to the pathophysiology of endometriosis, targeting …

Endometriosis is a chronic inflammatory gynecological disorder regulated by estrogen and characterized by the growth of endometrial tissue outside the uterus. We have previously demonstrated that mesenchymal stem cells (MSCs) contribute dir…