Lipoxin A4 Inhibits the Development of Endometriosis in Mice: The Role of Anti‐Inflammation and Anti‐Angiogenesis

Zhangye Xu, Feng Zhao, Feng Lin, Jinxia Chen, Ying‐Ping Huang, Yingping Huang
American journal of reproductive immunology (New York, N.Y. : 1989) · 2012 · vol. 67(6) , pp. 491–497 · doi:10.1111/j.1600-0897.2011.01101.x · PMID:22229383 · W1997465990
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Lipoxin A4 treatment significantly inhibited endometriosis progression in mice by reducing lesion size, pro-inflammatory factors, MMP9 activity, and VEGF levels.

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Abstract

PROBLEM: To evaluate the effects of the anti-inflammatory and anti-angiogenic roles of LXA4 on endometriosis in mice. METHOD OF STUDY: Endometriosis was induced in 40 mice and separated into two groups. LXA4 group was administered by LXA4 for 3 weeks. The endometriotic lesions were counted, measured, and identified by pathology. The presence of a panel of pro-inflammatory factors was assessed by real-time RT-PCR, and enzyme-linked immunoassay, the mRNA, protein levels of matrix metalloproteinase (MMPs), and vascular endothelial growth factor (VEGF) were determined by real-time RT-PCR and immunohistochemistry; the activity of MMPs was evaluated by gelatin zymography. RESULTS: Treatment with LXA4 significantly inhibited endometriotic lesion development (13.58 ± 4.01 mm(2) in LXA4 group and 23.20 ± 7.49 mm(2) , P = 0.0002), downregulated pro-inflammatory factors, suppressed the activity of MMP9, and reduced the VEGF levels associated with endometriosis in mice. CONCLUSION: LXA4 may inhibit the progression of endometriosis possibly by anti-inflammation and anti-angiogenesis.

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Condition tags

endometriosis

MeSH descriptors

Angiogenesis Inhibitors Anti-Inflammatory Agents, Non-Steroidal Endometriosis Lipoxins Angiogenesis Inhibitors Angiogenesis Inhibitors Animals Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal Cytokines Cytokines Cytokines Endometriosis Endometriosis Endometriosis Female Lipoxins Lipoxins Matrix Metalloproteinase 9 Matrix Metalloproteinase 9

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