Translational animal models for endometriosis research: a long and windy road

Antonio Simone Laganà, Simone Garzon, Massimo Franchi, Massimo Piergiuseppe Franchi, Jvan Casarin, Giuseppe Gullo, Fabio Ghezzi
Annals of translational medicine · 2018 · vol. 6(22) , pp. 431 · doi:10.21037/atm.2018.08.24 · PMID:30596061 · W2888408055
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This review discusses the challenges and progress in developing translational animal models for studying endometriosis, a chronic, estrogen-dependent disease impacting women's reproductive health.

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Abstract

Endometriosis is a chronic estrogen-dependent disease affecting 5–10% of women in reproductive age (1). Although it can be asymptomatic in a minority of the cases, the main symptoms and signs include chronic pelvic pain, dysmenorrhea, pain during intercourse, abnormal uterine bleeding and infertility, which may cause severe impact on patient’s psychological wellbeing and quality of life (2).
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Acknowledgements

None. Footnote Conflicts of Interest: The authors have no conflicts of interest to declare.

References

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endometriosischronic_pelvic_paindysmenorrheainfertility

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