Murine Models of Endometriosis: A Systematic Review

Hayedeh Hoorsan, Masoumeh Simbar, Fahimeh Ramezani Tehrani, Fardin Fathi, Nariman Mosaffa, Hedyeh Riazi, Omid Banafshi
In: International Journal of Women's Health and Reproduction Sciences · 2021 · vol. 10(3) , pp. 121–134 · doi:10.15296/ijwhr.2022.23 · W4289539959
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This systematic review compared homologous and heterologous murine models of endometriosis, finding homologous models better for pathogenesis studies and heterologous models for therapeutic studies.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This systematic review evaluated how murine models of endometriosis are established and used, focusing on comparisons between homologous (autologous-like) and heterologous transplantation approaches, with outcomes including lesion histopathology, biomarkers, and development of endometrial lesions. The authors searched PubMed, Scopus, Web of Cochrane, and EMBASE (1990–2019) and included experimental studies where model establishment was verified using measures such as implant size/weight/number, adhesions, histologic scores, and biomarker alterations. They found that heterologous induction was generally less reliable than autologous induction, while homologous induction produced larger lesions and biomarker and reproductive changes resembling those in humans. The paper concludes that heterologous models using human endometrial tissue under immunosuppression may be suitable for therapeutic studies but require attention to time limitations, and it emphasizes model choice based on study purpose. This paper is centrally about endometriosis — it systematically reviews murine endometriosis modeling via homologous and heterologous transplantation methods.

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Abstract

Objectives: This review inspects the usage of animal models and the practical solutions of this method for different challenges of endometriosis. The objectives of the study are to determine and compare the histopathology, biomarkers, and development of endometrial lesions in murine homologous and heterologous endometriosis models. Methods: The literature search was performed on PubMed, Scopus, Web Cochrane, and EMBASE from January 1990 to January 2019. Experimental articles in which the establishment of the endometriosis model had been proven through the examination of size, weight, number of implants, adhesion, histologic score, and altered biomarker were eligible for inclusion. Results: Based on type of induction, articles were categorized into two groups: heterologous-induced method (n=5) and autologousinduced method (n=13). In general, in case of establishing the heterologous induction method is less reliable than the autologous induction method. Conclusions: Using human endometrial tissues for endometrial inductions is possible in heterologous models under immunosuppression, which is more suitable for therapeutic studies, but time limitation considerations are mandatory for this type of model. Homologous endometriosis inductions cause larger endometrial lesions, biomarkers, and reproduction rate changes similar to those occurring in humans. Similarities make this method more appropriate for pathogenesis and genetic studies and also observe the impact of endometriosis on the next generation. Choosing an appropriate model for the induction of endometriosis is dependent on the purpose of each study.
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Jul 2022, Vol 10, Issue 3 Advanced Search For Author's & Reviewer's Poll How do you find the scientific quality of the published articles on our web site? | Review | | | Murine Models of Endometriosis: A Systematic Review | | | Hayedeh Hoorsan1, Masoumeh Simbar2, Fahimeh Ramezani Tehrani3, Fardin Fathi4, Nariman Mosaffa5, Hedyeh Riazi6, Omid Banafshi4 | | | 1Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2Midwifery and Reproductive Health Research Center, Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran 3Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran 4Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran 5Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran 6Department of Midwifery & Reproductive Health, School of Nursing & Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran | | | IJWHR 2022; 10: 121-134 DOI: 10.15296/ijwhr.2022.23 Viewed : 3313 times Downloaded : 6105 times. Keywords : Endometriosis, Animal models, Homologous transplantation, Heterologous transplantation | | | Full Text(PDF) | Related Articles | | | Abstract | | Objectives: This review inspects the usage of animal models and the practical solutions of this method for different challenges of endometriosis. The objectives of the study are to determine and compare the histopathology, biomarkers, and development of endometrial lesions in murine homologous and heterologous endometriosis models. Methods: The literature search was performed on PubMed, Scopus, Web Cochrane, and EMBASE from January 1990 to January 2019. Experimental articles in which the establishment of the endometriosis model had been proven through the examination of size, weight, number of implants, adhesion, histologic score, and altered biomarker were eligible for inclusion. Results: Based on type of induction, articles were categorized into two groups: heterologous-induced method (n=5) and autologous-induced method (n=13). In general, in case of establishing the heterologous induction method is less reliable than the autologous induction method. Conclusions: Using human endometrial tissues for endometrial inductions is possible in heterologous models under immunosuppression, which is more suitable for therapeutic studies, but time limitation considerations are mandatory for this type of model. Homologous endometriosis inductions cause larger endometrial lesions, biomarkers, and reproduction rate changes similar to those occurring in humans. Similarities make this method more appropriate for pathogenesis and genetic studies and also observe the impact of endometriosis on the next generation. Choosing an appropriate model for the induction of endometriosis is dependent on the purpose of each study. | Cite By, Google Scholar Articles by Hoorsan H Articles by Simbar M Articles by Ramezani Tehrani F Articles by Fathi F Articles by Mosaffa N Articles by Riazi H Articles by Banafshi O Articles by Hayedeh Hoorsan Articles by Masoumeh Simbar Articles by Fahimeh Ramezani Tehrani Articles by Fardin Fathi Articles by Nariman Mosaffa Articles by Hedyeh Riazi Articles by Omid Banafshi Submit Paper Online Submission System IJWHR ENDNOTE ® Style Tutorials Publication Charge Women's Reproductive Health Research Center About Journal Online Submission System IJWHR ENDNOTE ® Style Tutorials Publication Charge Women's Reproductive Health Research Center About Journal Publication Information Publisher Aras Part Medical International Press Editor-in-Chief Arash Khaki Mertihan Kurdoglu Deputy Editor Zafer Akan Aras Part Medical International Press Editor-in-Chief Arash Khaki Mertihan Kurdoglu Deputy Editor Zafer Akan Published Article Statistics

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