An Influence of Immunomodulation on Th1 and Th2 Immune Response in Endometriosis in an Animal Model

K Szymanowski, Krzysztof Szymanowski, Joanna Niepsuj-Biniaś, J Niepsuj-Biniaś, A Dera-Szymanowska, Anna Dera-Szymanowska, Maria Wołuń-Cholewa, M Wołuń-Cholewa, A Yantczenko, Andrey Yantczenko, E Florek, Ewa Florek, T Opala, Tomasz Opala, Marek Murawski, M Murawski, K Wiktorowicz
BioMed research international · 2013 · vol. 2013 , pp. 1–7 · doi:10.1155/2013/849492 · PMID:24298555 · W2141799028
article OA: hybrid CC0 ⤵ 17 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study assessed how the RESAN immunomodulator influenced Th1 and Th2 immune responses in a rat model of endometriosis, finding that RESAN demonstrated a Th2 response that inhibited disease development.

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Abstract

AIM: To assess the role of the Th1 and Th2 cellular response in the etiology of endometriosis observed in a rat model, with the use of the RESAN immunomodulator. MATERIALS AND METHODS: A comparative analysis of cytokines in blood serum typical of Th1 (TNF-α and INF-γ ) and Th2 (IL-4, IL-6, IL-10) cell response in groups of rats, in which RESAN preparation was used as prophylaxis (Gr. I) or treatment (Gr. II) of endometriosis. RESULTS: The results indicated an increase in the level of cytokines in blood serum typical of Th2 cell response by comparing the second and third stages of the experiment in the second group of rats and a decrease in IL-4 and IL-10 between III and IV stages. There was a significant difference in cytokine levels during the third stage of the experiment by comparing I and II groups of rats. In the III group of rats, levels of IL-10 significantly increased between the II and III stages of the experiment. CONCLUSION: RESAN preparation shows Th2 cell response, inhibiting the development of endometriosis in a rat model. Due to successful prophylactic action, one may speculate that RESAN vaccine may be effective as a complementary treatment after surgical excision.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Cancer Vaccines Endometriosis Endometriosis Immunomodulation Th1 Cells Th2 Cells Animals Cancer Vaccines Disease Models, Animal Endometriosis Endometriosis Female Immunologic Factors Immunologic Factors Interferon-gamma Interferon-gamma Interleukin-10 Interleukin-10 Interleukin-4 Interleukin-4

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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