Translational Animal Models to Study Endometriosis-Associated Infertility
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Abstract
Although there is an apparent association between endometriosis and impaired fertility, the pathophysiology of the reduced fecundity in women with endometriosis still remains unclear. Reproduction is a complex and multifactorial process, and possible factors contributing to the reduced fertility of endometriosis patients include defective function of the ovary, gametes, and endometrium as well as developmental disorders of the embryo. Because controlled experiments in humans are limited due to ethical reasons, experimental animal models have been developed mainly in nonhuman primates and laboratory rodents by induction of endometriosis via autologous transplantation of endometrial tissue. Animals with induced endometriosis reveal an impairment of fecundity similar to the situation described for humans and have been used to identify effects of ectopic endometrial tissue on adhesion formation, peritoneal fluid composition, ovarian function, endometrial gene expression, and embryo implantation. These animal models of endometriosis yield a valuable tool to study the mechanisms of endometriosis-associated infertility especially during the onset of the disease that cannot be investigated in women.
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Cited by (17)
- What We Have Learned from Animal Models to Understand the Etiology and Pathology of Endometrioma-Related Infertility 2022
- Endometriosis-associated infertility: From pathophysiology to tailored treatment 2022
- Murine Models of Endometriosis: A Systematic Review 2021
- The Link Between Stress and Endometriosis: from Animal Models to the Clinical Scenario 2020
- Decidual Differentiation of Endometrial Cell Lines in the Norm and Pathological Conditions 2020
- Establishment of endometriotic models: the past and future 2020
- Dose-Dependent Decreased Fertility in Response to the Burden of Endometriosis in a Murine Model 2019
- PI3K/AKT pathway is altered in the endometriosis patient’s endometrium and presents differences according to severity stage 2019
- Endometriosis Knowledgebase: a gene-based resource on endometriosis 2019
- Translational animal models for endometriosis research: a long and windy road 2018
- Endometriosis 2018
- Gynecologic Health and Disease Research at the Eunice Kennedy Shriver National Institute of Child Health and Human Development 2018
- Rodent Models of Experimental Endometriosis: Identifying Mechanisms of Disease and Therapeutic Targets 2018
- Environmental Manipulations as an Effective Alternative Treatment to Reduce Endometriosis Progression 2017
- Uterine Leukocyte Function and Dysfunction: A Hypothesis on the Impact of Endometriosis 2016
- Endometriosis ☆ 2014
- A Novel Mouse Model of Endometriosis Mimics Human Phenotype and Reveals Insights into the Inflammatory Contribution of Shed Endometrium 2014
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- openalex
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