Development of an experimental model of endometriosis in rats.

Vivian Ferreira do Amaral, Eduardo Andreazza Dal Lago, William Kondo, Luiz César Guarita Souza, Júlio César Francisco
Revista do Colegio Brasileiro de Cirurgioes · 2009 · vol. 36(3) , pp. 250–5 · PMID:20076906 · W2085435188
article OA: closed CC0 ⤵ 14 in-corpus citations
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This study developed an experimental endometriosis model in rats by implanting uterine horn segments onto the abdominal wall, observing successful lesion development in most subjects at 30 and 60 days post-surgery.

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Abstract

OBJECTIVES: To develop an experimental model of endometriosis in rats. METHODS: Thirty adult female Wistar rats were used. The surgical technique consisted of median laparotomy with identification of the bicornuate uterus and resection of a 2-cm segment of the right uterine horn. A 0.25 cm(2) flap was removed from that structure and sutured to the abdominal wall with the endometrial side facing the peritoneal cavity. The rats were randomly divided into two groups according to the reoperation date: group 1 (n=15) was reoperated in 30 days, and group 2 (n=15), in 60 days. On the occasion of the second laparotomy, the implants were evaluated macroscopically, resected and referred for microscopic analysis with hematoxylin-eosin and immunohistochemical staining (HEMA, AE1 and AE2). RESULTS: The implants developed in 83.3 % of group 1 and 71.4% of group 2. There was no statistically significant difference between the weights of the animals in the two groups. No statistically significant difference was found in the surface area of the induced lesions: in group 1, the mean was 0.37 cm(2) and in group 2, 0.25 cm(2). According to Keenan's semiquantitative histological classification (based on the preservation status of the epithelial layer of the endometrium), the mean for group 1 was 1.9 and for group 2, 2.4. CONCLUSION: The technique used for inducing the development of endometriosis in rats was satisfactory.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Disease Models, Animal Endometriosis Animals Female Rats Rats, Wistar

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (32)

Cited by (14)

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