Effect of the bone marrow derived-mononuclear stem cells transplantation in the growth, VEGF-R and TNF-alpha expression of endometrial implants in Wistar rats

William Kondo, Kondo W, Eduardo Andreazza Dal Lago, Dal Lago EA, Francisco JC, Júlio César Francisco, Julio Cesar Francisco, Simeoni RB, Rossana Baggio Simeoni, Lúcia de Noronha, de Noronha L, Lucia de Noronha, Ana Paula Camargo Martins, Martins AP, Marina Luise Viola de Azevedo, de Azevedo ML, Ferreira CC, Carolina Chaves Ferreira, Priscila Maestrelli, Maestrelli P, Marcia Olandoski, Olandoski M, Márcia Olandoski, Luiz Cesar Guarita-Souza, Luiz César Guarita-Souza, do Amaral VF, Vivian Ferreira do Amaral
European journal of obstetrics, gynecology, and reproductive biology · 2011 · vol. 158(2) , pp. 298–304 · doi:10.1016/j.ejogrb.2011.05.004 · PMID:21640466 · W2015245112
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Bone marrow-derived mononuclear stem cells were transplanted into Wistar rats to investigate their effects on the growth and expression of VEGF-R and TNF-alpha in endometrial implants.

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Abstract

ObjectiveTo study the effect of bone marrow derived-mononuclear stem cells transplantation in the growth, VEGF-R and TNF-alpha expression of surgically induced endometriosis in an experimental model.Study designThis is an experimental study conducted in the Center for Health and Biological Sciences at the Pontifical Catholic University of Parana, Brazil. Endometriotic implants were surgically induced in 120 female Wistar rats. The animals with viable endometrial implant (larger than 25 mm(2)) were randomically divided into 3 groups to receive an intraperitoneal injection of 0.2 cc of saline solution (C group; n=30), a subcutaneous injection of 1mg/kg of leuprolide (L group; n=34), or an intraperitoneal injection of 5×10(6) bone marrow derived-mononuclear stem cells (SC group; n=36). They were sacrificed after 21 days to assess the implants' size and the tissue expression of vascular endothelial growth factor receptor (VEGF-R) and tumor necrosis factor-alpha (TNF-alpha).ResultsTreatment with leuprolide decreased the surface area of the endometriotic implant compared to the SC group and the C group. The absolute reduction in the surface area of the implant was 16.5mm, 0mm, and 0mm (p=0.007), respectively, and the percent reduction was 40.2%, 0%, and 0% (p=0.001). VEGF-R expression in the endometriotic implant decreased after treatment in the L and SC groups compared to the C group (409.6 μm(2) vs. 465 μm(2) vs. 920.9 μm(2), respectively; p=0.021). TNF-alpha expression also reduced in the L and SC groups compared to the C group (585.7 μm(2) vs. 549.3 μm(2) vs. 2402.1 μm(2), respectively; p<0.001).ConclusionBone marrow derived-mononuclear stem cells transplantation decreased the expression of VEGF-R and TNF-alpha in the endometriotic implant but did not reduce the surface area of the lesion.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Receptors, Vascular Endothelial Growth Factor Stem Cell Transplantation Tumor Necrosis Factor-alpha Animals Bone Marrow Disease Models, Animal Endometriosis Endometriosis Female Fertility Agents, Female Fertility Agents, Female Injections, Intraperitoneal Leuprolide Leuprolide Rats Rats, Wistar Receptors, Vascular Endothelial Growth Factor Tumor Necrosis Factor-alpha

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