Effect of anti-TNF- Effect of anti-TNF- Effect of anti-TNF- Effect of anti-TNF- Effect of anti-TNF- a on peritoneal endometrial implants of rats

Kondo Kondo
2011 · W2607342829
article OA: closed CC0 Metadata only
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This study found that while anti-TNF-alpha therapy reduced TNF-alpha expression in rat peritoneal endometrial implants, it did not decrease implant size, unlike leuprolide treatment.

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Abstract

Objective: To evaluate the effect of anti-TNF- a in the treatment of endometrial implants in the peritoneum of rats. Methods: Endometrial implants were surgically induced in 120 female Wistar-Albino rats. The animals were randomly divided into four groups. Group C (n = 36) received an intraperitone al injection of 0.2 ml of saline. Group L (n = 41) received a subcutaneous injection of 1mg/kg of leuprolide. Group I5 (n = 20) received a subcutaneous injection of 5mg/kg of monoclonal anti-tumor necrosis factor (TNF) a (infliximab). Group I10 (n = 20) received a subcutaneous injection of 10mg/kg of infliximab. The rats were sacrificed after 21 days to assess the size of the implants and the expression of TNF. Results: Treatment with leuprolide (group L) promoted an absolute reduction in the surface area of the implant when compared with group C (+14 mm vs. 0mm, p = 0.013) and group I10 (+14 mm vs. +5 Mm, p = 0.018). Likewise, a percentage reduction of surface area of the implant was observed comparing group L with group C (+33.3% vs. 0%, p = 0.005) and group I10 (+33.3% vs. +18.3%, p = 0.027). Treatment with infliximab was not able to decrease the surface area of the implants when compared with group C. The expression of TNF- a in groups L, I5 and I10 was lower than in group C (505.6 mm 2 vs. 660.5 mm 2 vs. 317.2 mm 2 vs. 2519.3 mm 2 , respectively; p <0.001). Conclusion: The anti-TNF-a therapy reduced the expression of TNF- a in endometriotic implants, but did not reduce the surface area of the lesion.

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