Therapeutic potential of curcumin in endometrial disorders: Current status and future perspectives

Apoorva Singh, Sanjukta Dasgupta, Anindita Bhattacharya, Gayatri Mukherjee, Mukherjee G, Koel Chaudhury
Drug discovery today · 2021 · vol. 27(3) , pp. 900–911 · doi:10.1016/j.drudis.2021.11.010 · PMID:34775103 · W3213185823
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This review explores the therapeutic potential of curcumin for endometrial disorders, discussing its current status and future research directions.

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Abstract

Endometrial disorders collectively encompass a broad spectrum of pathologies, including but not limited to endometriosis, endometrial cancer and endometritis. The current therapeutic management of these diseases is associated with several limitations. This has prompted interest in the use of plant-based bioactive compounds as alternative strategies to achieve high therapeutic efficacy and avoid adverse effects. In this context, curcumin, a polyphenol abundantly present in turmeric, is gaining increasing attention for its therapeutic potential to restore homeostasis in endometrial dysfunctionality. We comprehensively review the multifaceted role of curcumin, discussing mechanistic insights in various endometrial pathologies. We also provide an in-depth analysis of the concerns and challenges associated with the role of curcumin in endometrial research and outline a road map for future investigations.

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Condition tags

endometriosis

MeSH descriptors

Curcumin Curcumin Curcumin Endometriosis Endometriosis Endometriosis Female Forecasting Humans

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License: CC0 · commercial use OK