Nonsteroidal antiinflammatory drugs differentially suppress endometriosis in a murine model

Jason A Efstathiou, Efstathiou JA, David A Sampson, Sampson DA, Zalman Levine, Levine Z, Richard M Rohan, Rohan RM, David Zurakowski, Zurakowski D, Judah Folkman, Folkman J, D'Amato RJ, Robert J D'Amato, Robert J. D’Amato, Rupnick MA, Maria A Rupnick
Fertility and Sterility · 2005 · vol. 83(1) , pp. 171–181 · doi:10.1016/j.fertnstert.2004.06.058 · PMID:15652904 · W2042315716
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This study investigated the effects of nonsteroidal anti-inflammatory drugs on endometriosis in mice, finding differential suppression among the tested drugs.

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Abstract

ObjectiveTo determine whether nonsteroidal antiinflammatory drugs (NSAIDs) affect the establishment and progression of endometriotic lesions in a murine model.DesignPharmacologic intervention in a surgically induced murine model of abdominal/peritoneal endometriosis.SettingAnimal research facility.Patient(s)Eight-week-old, female C57BL/6 mice.Intervention(s)After implantation of autologous endometrium, mice were randomized into groups and treated with one of several NSAIDs or the vehicle-matched control for 4 weeks.Main outcome measure(s)Establishment, growth, and total burden of endometriotic lesions.Result(s)The NSAIDs differentially inhibited lesion establishment and growth, resulting in significantly reduced disease burden. Compared with controls (5.7 +/- 2.3 mm(2)), lesion burden was reduced by celecoxib (1.3 +/- 1.2 mm(2)), indomethacin (1.4 +/- 1.4 mm(2)), naproxen (2.7 +/- 1.2 mm(2)), sulindac (3.1 +/- 1.5 mm(2)), rofecoxib (3.4 +/- 3.0 mm(2)), and ibuprofen (4.1 +/- 1.4 mm(2)). In contrast, aspirin (5.9 +/- 1.2 mm(2)) had no statistically significant effect. Uninterrupted estrus cycling was confirmed by vaginal exams and smears in celecoxib-treated mice.Conclusion(s)Chronic administration of certain NSAIDs limits the progression of endometriosis in this murine model. The data suggest that NSAID selection in the treatment of endometriosis should be extended beyond pain management to maximize the inhibitory effect on disease burden.

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Condition tags

endometriosis

MeSH descriptors

Anti-Inflammatory Agents, Non-Steroidal Cyclooxygenase Inhibitors Endometriosis Pyrazoles Sulfonamides Animals Anti-Inflammatory Agents, Non-Steroidal Celecoxib Cyclooxygenase Inhibitors Disease Models, Animal Endometriosis Endometriosis Female Humans Mice Mice, Inbred C57BL Pyrazoles Sulfonamides

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (50)

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