Indomethacin and fertility in experimental endometriosis.

R Dargenio, Dargenio R, Ruggero Dargenio, Corbucci Mg, M G Corbucci, Lamanna Ma, M A Lamanna, Garcea N, N Garcea
Acta Europaea fertilitatis · 1993 · vol. 23(2) , pp. 85–8 · PMID:1295281 · W2418692915
article OA: closed CC0 ⤵ 8 in-corpus citations
View on OpenAlex View on PubMed
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-09 ⓘ

Indomethacin treatment during the pre-ovulatory phase in rats with induced endometriosis completely restored fertility, as evidenced by restored gestational sacs, corpora lutea counts, and nidation index.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Clinical and experimental evidence showed an increased concentration of prostaglandins in peritoneal fluid in cases of endometriosis. The aim of this study was to verify whether an antiprostaglandin drug can restore fertility in cases of endometriosis. For this reason endometriosis was induced in 4 groups of 10 rats. Group A was treated with indomethacin both in the pre-ovulatory and in the post-ovulatory phase. Group B was treated in the pre-ovulatory phase. Group C was treated in the post-ovulatory phase. Group D was not treated. Ten other rats (group E) underwent a sham operation and were used as a control. Twelve days after mating, gestational sacs and corpora lutea were counted and the nidation index was calculated. Only indomethacin administered during the pre-ovulatory phase completely restored fertility in these rats.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Indomethacin Infertility, Female Peritoneal Neoplasms Animals Disease Models, Animal Drug Administration Schedule Endometriosis Female Indomethacin Indomethacin Infertility, Female Infertility, Female Injections, Intramuscular Peritoneal Neoplasms Pregnancy Prostaglandins Prostaglandins Rats Rats, Wistar

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (8)

Source provenance

europepmc
last seen: 2026-08-25T06:10:03.373225+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:11:49.821429+00:00
License: CC0 · commercial use OK