Indomethacin and fertility in experimental endometriosis

R Dargenio, Dargenio R, Ruggero Dargenio, Corbucci Mg, M G Corbucci, Lamanna Ma, M A Lamanna, Garcea N, N Garcea
Acta Europaea fertilitatis · 1993 · vol. 23(2) , pp. 85–8 · PMID:1295281 · W2418692915
Lab / animal OA: closed CC0 ⤵ 8 in-corpus citations
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Indomethacin treatment during the pre-ovulatory phase in rats with induced endometriosis completely restored fertility, as evidenced by restored gestational sacs, corpora lutea counts, and nidation index.

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Abstract

Clinical and experimental evidence showed an increased concentration of prostaglandins in peritoneal fluid in cases of endometriosis. The aim of this study was to verify whether an antiprostaglandin drug can restore fertility in cases of endometriosis. For this reason endometriosis was induced in 4 groups of 10 rats. Group A was treated with indomethacin both in the pre-ovulatory and in the post-ovulatory phase. Group B was treated in the pre-ovulatory phase. Group C was treated in the post-ovulatory phase. Group D was not treated. Ten other rats (group E) underwent a sham operation and were used as a control. Twelve days after mating, gestational sacs and corpora lutea were counted and the nidation index was calculated. Only indomethacin administered during the pre-ovulatory phase completely restored fertility in these rats.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Indomethacin Infertility, Female Peritoneal Neoplasms Animals Animals Disease Models, Animal Disease Models, Animal Drug Administration Schedule Drug Administration Schedule Endometriosis Endometriosis Female Female Indomethacin Indomethacin Indomethacin Infertility, Female Infertility, Female Infertility, Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

Cited by (8)

Source provenance

europepmc
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openalex
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pubmed
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License: CC0 · commercial use OK