Serum and Peritoneal Fluid Levels of Vascular Endothelial Growth Factor in Women with Endometriosis

Maryam Kianpour, Mehdi Nematbakhsh, Sayad Mehdi Ahmadi, Mehrangiz Jafarzadeh, Masomeh Hajjarian, Zahra Pezeshki, Tahereh Safari, Fatemeh Eshraghi-Jazi
In: International Journal of Fertility and Sterility, Vol 7, Iss 2, Pp 96-99 (2013) · 2013 · W4390689013
article OA: green CC0 ⤵ 29 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that women with endometriosis have higher levels of vascular endothelial growth factor in peritoneal fluid compared to non-endometriosis patients, but no significant difference in serum levels.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This descriptive study measured vascular endothelial growth factor (VEGF) concentrations in paired peritoneal fluid and serum from 179 women undergoing laparoscopy for infertility or pelvic pain, comparing women with different types of endometriosis (n=90) to non-endometriosis controls (n=89). VEGF in serum was significantly lower than in peritoneal fluid in both groups, and endometriosis patients showed higher VEGF levels in peritoneal fluid than controls. The study’s main limitation is that it reports VEGF differences using a cross-sectional design and does not provide mechanistic or longitudinal outcomes. This paper is centrally about endometriosis — it quantifies and compares serum and peritoneal-fluid VEGF levels between women with endometriosis and non-endometriosis controls.

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Abstract

Background: Endometriosis is known as one of the most common disease in women ofreproductive age. Due to important role of vascular endothelial growth factor (VEGF) inneo-vascularization for the implantation of endometrial cell, and also presence of differentstudies reported VEGF level in the serum and peritoneal fluid (PF) in endometriosispatients, this study was designed to determine the serum and PF levels of VEGF in endometriosispatients, and to compare with normal subjects.Materials and Methods: In this descriptive study, 179 women subjected to laparoscopyfor the evaluation of infertility or pelvic pain were allocated into the following two groups:group I: different types of endometriosis patients (n=90) and group II: non-endometriosispatients (n=89). The PF from pelvis and venous blood samples were obtained. The VEGFconcentration of the serum and PF were measured using enzyme immunoassay kit and werecompared using t test.Results: The level of VEGF in serum was significantly less than that in PF in both groups(p=0.00). However, endometriosis patients had significantly higher level of VEGF inperitoneal fluid than non-endometriosis patients (p=0.043).Conclusion: According to our findings, endometriosis is not associated with change inthe level of circulating VEGF.

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endometriosisinfertility

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