Analysis of VEGF, IGF1/2 and the Long Noncoding RNA (lncRNA) H19 Expression in Polish Women with Endometriosis

Beata Smolarz, Tomasz Szaflik, Hanna Romanowicz, Magdalena Bryś, Ewa Forma, Krzysztof Szyłło
International journal of molecular sciences · 2024 · vol. 25(10) , pp. 5271 · doi:10.3390/ijms25105271 · PMID:38791310 · W4396892214
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study analyzed VEGF, IGF1, and H19 gene expression in Polish women with endometriosis, finding elevated VEGF in early stages, decreased IGF1 across stages, and reduced H19 in advanced stages compared to controls.

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Abstract

The coordinated action of VEGF, IGF1/2 and H19 factors influences the development of endometriosis. The aim of this study was to analyze the expression level of these genes in patients with endometriosis. The study group consisted of 100 patients who were diagnosed with endometriosis on laparoscopic and pathological examination. The control group consisted of 100 patients who were found to be free of endometriosis during the surgical procedure and whose eutopic endometrium wasnormal on histopathological examination. These patients were operated on for uterine fibroids. Gene expression was determined by RT-PCR. The expression of the VEGF gene was significantly higher in the samples classified as clinical stage 1–2 compared to the control material (p < 0.05). There was also a statistically significant difference between the samples studied at clinical stages 1–2 and 3–4 (p < 0.01). The expression of the VEGF gene in the group classified as 1–2 was significantly higher. IGF1 gene expression was significantly lower both in the group of samples classified as clinical stages 1–2 and 3–4 compared to the control group (p < 0.05 in both cases). The expression of the H19 gene was significantly lower in the group of samples classified as clinical stage 3–4 compared to the control group (p < 0.01). The reported studies suggest significant roles of VEGF, IGF and H19 expression in the pathogenesis of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Insulin-Like Growth Factor I Insulin-Like Growth Factor I Insulin-Like Growth Factor I Insulin-Like Growth Factor I Insulin-Like Growth Factor I Insulin-Like Growth Factor I Insulin-Like Growth Factor I Insulin-Like Growth Factor I Insulin-Like Growth Factor I Insulin-Like Growth Factor II

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (65)

Cited by (4)

SciLite annotations

chemicals 18
nucleotide prostaglandin e2 estradiol 6beta-[n-(carboxymethylamino)carbonyl]methoxy-17beta-estradiol ethanol xylene ethanol guanidine sodium diethylcarbamazine citrate chloroform methanol ethyl piperidinoacetylaminobenzoate ethyl piperidinoacetylaminobenzoate sodium acetate water estrogen estrogen
organisms 4
mus sp. noordeloos 2009062 noordeloos 2009062 mus sp.

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