Гормональний гомеостаз у жінок репродуктивного віку з аденоміозом

В.О. Бенюк, В.В. Курочка, К.І. Сусак, Y.G. Drupp, О.О. Бала
In: Reproductive health of woman · 2022 · pp. 10–13 · doi:10.30841/2708-8731.7.2022.272464 · W4321845780
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated the hypothalamic-pituitary-ovarian system in women with adenomyosis, finding elevated gonadotropins and prolactin, alongside hyperestrogenemia and hypoprogesteronemia.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

The study examined hypothalamic–pituitary–ovarian system function in 120 reproductive-age women with benign uterine pathology including adenomyosis, endometrial hyperplasia, or combined disease, compared with 40 healthy controls, by measuring serum FSH, LH, prolactin, estradiol, and progesterone across menstrual cycle phases. Women with adenomyosis and related conditions showed hypersecretion of gonadotropins and prolactin (with increased average FSH, LH, and prolactin), plus additional FSH and LH peaks in both cycle phases, alongside hyperestrogenemia throughout the cycle and hypoprogesteronemia; the magnitude varied by specific pathology and functional state. A stated caveat is that the assessment relied on hormone measurements across phases without detailing causal mechanisms. This paper is centrally about endometriosis and adenomyosis — specifically adenomyosis-related disruption of hypothalamic–pituitary–ovarian hormonal homeostasis in reproductive-age women.

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Abstract

The problem of adenomyosis is particularly relevant for patients of reproductive age, as it is accompanied by the significant disturbances of menstrual and generative functions. The article presents the results of studying the condition of the hypothalamic-pituitary-ovarian system in women of reproductive age with adenomyosis.The objective: to study the state of the hypothalamic-pituitary-ovarian system in women of reproductive age with benign endometrial and myometrial pathology.Materials and methods. The main group included 120 women of reproductive age with benign endometrial and myometrial pathology (adenomyosis, endometrial hyperplasia and combined pathology), and the control group included 40 healthy women without gynecological pathology. The functional state of the hypothalamic-pituitary-ovarian system was evaluated by the levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), estradiol (E2) and progesterone (P) in blood serum in different phases of the menstrual cycle.Results. In women with adenomyosis, endometrial hyperplasia and combined pathology, there is hyperproduction of gonadotropic hormones with an increase of their secretion level compared to a group of healthy women: the average concentration of FSH, regardless of the phase of the menstrual cycle, increased by 1.9 times (p<0.05), LH – 2.2 times, PRL – 2 times, which indicates the presence of hyperprolactinemia. Both in the I and II phases of the menstrual cycle, the occurrence of additional FSH and LH peaks from basal hormone secretion was determined in patients of the main group, which reached the level of hormone concentration in the ovulatory peak. In the patients of the main group, hyperestrogenemia during the entire menstrual cycle and hypoprogesteronemia were detected. The expression of hormonal shifts depended on gynecological pathology (adenomyosis, endometrial hyperplasia and combined pathology) and the functional state of the woman.Conclusions. The indicators of gonadotropic and prolactin-stimulating activity of the pituitary gland in women with benign uterine pathology confirm the participation of FSH, LH and prolactin in the complex processes of regulation of the reproductive system.

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adenomyosis

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