Expression of focal adhesion kinase in endometrial stromal cells of women with endometriosis was adjusted by ovarian steroid hormones.

Lin Mu, Yan-Yan Ma, Yanyan Ma
International journal of clinical and experimental pathology · 2015 · vol. 8(2) , pp. 1810–5 · PMID:25973072 · W2273716019
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Abstract

The aim of our study is to investigate the effects of ovarian steroid hormones on focal adhesion kinase (FAK) expression in ESCs and whether there is alteration in women with endometriosis. FAK expression was assessed by western blotting analysis. Elevated expression of FAK was seen in the cultured ESCs treated with estrogen (P < 0.05). Expression of FAK protein was not changed in ESCs after treated by progesterone or treated by estrogen and progesterone. The level of up-regulation by estrogen in endometriosis is significantly higher than that from women without endometriosis (P < 0.05). FAK expression in endometrial stromal cells from endometriosis was more sensitive to estrogen, which might contribute to the pathogenesis and progress of endometriosis.

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mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometrium Estrogens Focal Adhesion Kinase 1 Progesterone Stromal Cells Adult Case-Control Studies Cells, Cultured Endometriosis Endometriosis Endometrium Endometrium Endometrium Estrogens Female Focal Adhesion Kinase 1 Humans Progesterone Stromal Cells

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