Expression of focal adhesion kinase in endometrial stromal cells of women with endometriosis was adjusted by ovarian steroid hormones

Lin Mu, Mu L, Ma YY, Yan-Yan Ma, Yanyan Ma
International journal of clinical and experimental pathology · 2015 · vol. 8(2) , pp. 1810–5 · PMID:25973072 · PMC4396327 · W2273716019
Lab / animal OA: green CC0 ⤵ 9 in-corpus citations
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Estrogen significantly elevated focal adhesion kinase expression in endometrial stromal cells, particularly in women with endometriosis, suggesting a role in disease pathogenesis.

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Abstract

The aim of our study is to investigate the effects of ovarian steroid hormones on focal adhesion kinase (FAK) expression in ESCs and whether there is alteration in women with endometriosis. FAK expression was assessed by western blotting analysis. Elevated expression of FAK was seen in the cultured ESCs treated with estrogen (P < 0.05). Expression of FAK protein was not changed in ESCs after treated by progesterone or treated by estrogen and progesterone. The level of up-regulation by estrogen in endometriosis is significantly higher than that from women without endometriosis (P < 0.05). FAK expression in endometrial stromal cells from endometriosis was more sensitive to estrogen, which might contribute to the pathogenesis and progress of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Estrogens Focal Adhesion Kinase 1 Progesterone Stromal Cells Adult Adult Case-Control Studies Case-Control Studies Cells, Cultured Cells, Cultured Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Estrogens

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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