Thrombospondin-1 Mimetic Peptide ABT-898 Affects Neovascularization and Survival of Human Endometriotic Lesions in a Mouse Model

Diane S Nakamura, Andrew K Edwards, Sophia Virani, Richard Thomas, Chandrakant Tayade
The American journal of pathology · 2012 · vol. 181(2) , pp. 570–582 · doi:10.1016/j.ajpath.2012.05.010 · PMID:22727957 · W2067925891
article OA: closed CC0 ⤵ 5 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

The thrombospondin-1 mimetic peptide ABT-898 was found to reduce neovascularization and improve lesion survival in a mouse model of human endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Neovascularization, Pathologic Oligopeptides Peptidomimetics Thrombospondin 1 Animals Cell Movement Cell Movement Cell Proliferation Cell Proliferation Cytokines Cytokines Disease Models, Animal Endometriosis Endometriosis Endometriosis Endometrium Endometrium Estrous Cycle

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References (51)

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License: CC0 · commercial use OK