The alpha(2)beta(1) and alpha(3)beta(1) integrins do not mediate attachment of endometrial cells to peritoneal mesothelium

Craig A. Witz, Sook Cho, Iris A Montoya-Rodriguez, Robert S. Schenken
Fertility and sterility · 2002 · vol. 78(4) , pp. 796–803 · doi:10.1016/s0015-0282(02)03340-x · PMID:12372459 · W2047249230
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This study investigated the role of α2β1 and α3β1 integrins in endometrial cell attachment to peritoneal mesothelium, finding they do not mediate this interaction.

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Abstract

OBJECTIVE: To evaluate the possible role of mesothelial alpha(2)beta(1) and alpha(3)beta(1) integrins in the attachment of endometrial stromal cells (ESCs) and endometrial epithelial cells (EECs). DESIGN: In vitro study. SETTING: University medical center. PATIENT(S): Women of reproductive age (n = 26). MAIN OUTCOME MEASURE(S): Mesothelial cells were grown on collagen IV. Endometrial stromal cells and EECs were plated on mesothelial cells for 1 hour. Before plating, mesothelial cells or endometrial cells were incubated with antibodies to alpha2, alpha3, and beta1 integrin subunits. The effect of these antibodies on ESC and EEC binding to collagen IV and collagen I was also examined. The expression of collagen I, collagen IV, fibronectin, and laminin by cultured ESCs and EECs was examined. RESULT(S): The anti-integrin antibodies had no effect on endometrial binding to mesothelium. The beta1 integrin antibody decreased binding of ESCs and EECs to the collagen matrices. In culture, ESCs and EECs expressed collagen I, collagen IV, fibronectin, and laminin to varying degrees. CONCLUSION(S): The initial adhesion of ESCs and EECs to mesothelium is not mediated by beta1 integrins. In contrast, ESC and EEC attachment to collagen IV and collagen I, which are present in the submesothelial extracellular matrix, is mediated by beta1 integrins.

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MeSH descriptors

Endometrium Epithelium Integrin alpha2beta1 Integrin alpha3beta1 Peritoneum Adult Antibodies Antibodies Cell Adhesion Cell Adhesion Cells, Cultured Collagen Type I Collagen Type I Collagen Type I Collagen Type IV Collagen Type IV Collagen Type IV Culture Media Endometrium Epithelium

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