Avaliação de marcadores de proliferação celular e apoptose em tecido endometrial eutópico e ectópico em modelo experimental de endometriose em coelhas

Julio Cesar Rosa e Silva
In: Universidade de São Paulo · 2007 · doi:10.11606/t.17.2007.tde-26092013-162027 · W1964561615
dissertation OA: gold CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study evaluated cell proliferation and apoptosis markers in eutopic and ectopic endometrial tissue in a rabbit model of endometriosis, finding similar histological aspects between the tissues.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This thesis studied cell proliferation and apoptosis markers in endometrial eutopic versus ectopic tissue in an experimental endometriosis model in rabbits, using tissue-level indices derived from markers such as PCNA (proliferation) and measures of apoptosis, alongside an “index of tissue homeostasis” (IHT). The work compared these markers across eutopic and ectopic endometrial sites in the animal model, reporting findings through calculated proliferation and apoptosis indices and discussing them in relation to tissue homeostasis and remodeling. A key limitation explicitly reflected in the thesis framing is that results are based on an experimental animal model and tissue marker indices rather than direct clinical outcomes in humans. This paper is centrally about endometriosis — it evaluates proliferation and apoptosis biomarkers in eutopic and ectopic endometrial tissue using an experimental endometriosis model in rabbits.

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Abstract

Although the histological aspects were similar, the lesions

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